March 2018

J Psychiatry Neurosci 2018;43(2)


Is poststroke depression the same as major depression?
P.R. Albert

Research Papers

Grey matter correlates of autistic traits in women with anorexia nervosa
M. Björnsdotter, M. Davidovic, L. Karjalainen, G. Starck, H. Olausson, E. Wentz

Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex
P. Prini, F. Rusconi, E. Zamberletti, M. Gabaglio, F. Penna, M. Fasano, E. Battaglioli, D. Parolaro, T. Rubino

A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia
J.S. Lum, S.J. Millard, X.-F. Huang, L. Ooi, K.A. Newell

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study
V. Onete, R.M. Henry, S.J.S. Sep, A. Koster, C.J. van der Kallen, P.C. Dagnelie, N. Schaper, S. Köhler, K. Reesink, C.D.A. Stehouwer, M.T. Schram

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder
A.H. Islam, A.W.S. Metcalfe, B.J. MacIntosh, D.J. Korczak, B.I. Goldstein

Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis
X. Gao, W. Zhang, L. Yao, Y. Xiao, L. Liu, J. Liu, S. Li, B. Tao, C. Shah, Q. Gong, J.A. Sweeney, S. Lui

Psychopharmacology for the Clinician

Covert dysphagia and recurrent pneumonia related to antipsychotic treatment
J.T. Stewart

January 2018

J Psychiatry Neurosci 2018;43(1)


Culture as an ingredient of personalized medicine
K. Matheson, A. Bombay, H. Anisman

Review Paper

Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence
J.E. Boyd, R.A. Lanius, M.C. McKinnon

Research Papers

Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder
K. Feldker, C.Y. Heitmann, P. Neumeister, L. Brinkmann, M. Bruchmann, P. Zwitserlood, T. Straube

Always on guard: emotion regulation in women with borderline personality disorder compared to nonpatient controls and patients with cluster-C personality disorder
L. van Zutphen, N. Siep, G.A. Jacob, G. Domes, A. Sprenger, B. Willenborg, R. Goebel, A. Arntz

Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men
Q. Li, J. Liu, W. Wang, Y. Wang, W. Li, J. Chen, J. Zhu, X. Yan, Y. Li, Z. Li, J. Ye, W. Wang

Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression
B. Romeo, W. Choucha, P. Fossati, J-Y. Rotge


2017 Reviewers

Psychopharmacology for the Clinician

Pharmacological management of neuropsychiatric symptoms in patients with major neurocognitive disorders
D. Elie, S. Rej

Clozapine, elevated heart rate and QTc prolongation
D.D. Kim, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn

November 2017

J Psychiatry Neurosci 2017;42(6)


The value of a skeptical approach to neurosciences in psychiatric training and practice
A. Traicu, R. Joober

Research Papers

Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels
M. Weiler, B. Machado de Campos, C. Vieira de Ligo Teixeira, R.F. Casseb, A.F. Mac Knight Carletti-Cassani, J.E. Vicentini, T.N. Cardoso Magalhães, L.L. Talib, O.V. Forlenza, M.L. Figueredo Balthazar

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder
M.A. Fullana, X. Zhu, P. Alonso, N. Cardoner, E. Real, C. López-Solà, C. Segalàs, M. Subirà, H. Galfalvy, J.M. Menchón, H.B. Simpson, R. Marsh, C. Soriano-Mas

Refinement by integration: aggregated effects of multimodal imaging markers on adult ADHD
T. Wolfers, A.L. Arenas, A.M.H. Onnink, J. Dammers, M. Hoogman, M.P. Zwiers, J.K. Buitelaar, B. Franke, A.F. Marquand, C.F. Beckmann

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness
O.G. Rus, T.J. Reess, G. Wagner, M. Zaudig, C. Zimmer, K. Koch

Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder
F.D. Zeeb, Z. Li, D.C. Fisher, M.H. Zack, P.J. Fletcher

Altered intrinsic functional brain architecture in female patients with bulimia nervosa
L. Wang, Q.-M. Kong, K. Li, X.-N. Li, Y.-W. Zeng, C. Chen, Y. Qian, S.-J. Feng, J.-T. Li, Y. Su, C.U. Correll, P.B. Mitchell, C.-G. Yan, D.-R. Zhang, T.-M. Si

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact
C. Kowalchuk, C. Teo, V. Wilson, A. Chintoh, L. Lam, S.M. Agarwal, A. Giacca, G.J. Remington, M.K. Hahn

Psychopharmacology for the Clinician

Treatment of ADHD in patients with bipolar disorder
R. Girard, R. Joober

September 2017

J Psychiatry Neurosci 2017;42(5)


Psychiatric genetics — Does diagnosis matter?
M. Alda


The neurobiology of transition to psychosis: clearing the cache
L. Palaniyappan, T. Das, K. Dempster

OCD: obsessive–compulsive … disgust? The role of disgust in obsessive–compulsive disorder
T. Bhikram, E. Abi-Jaoude, P. Sandor

Research Papers

Age-related brain structural alterations as an intermediate phenotype of psychosis
J. Dukart, R. Smieskova, F. Harrisberger, C. Lenz, A. Schmidt, A. Walter, C. Huber, A. Riecher-Rössler, A. Simon, U.E. Lang, P. Fusar-Poli, S. Borgwardt

Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients
I.K. Wium-Andersen, M.K. Wium-Andersen, M.B. Jørgensen, M. Osler

Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study
S.B.J. Koch, M. van Zuiden, L. Nawijn, J.L. Frijling, D.J. Veltman, M. Olff

Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder
N. Opel, R. Redlich, D. Grotegerd, K. Dohm, D. Zaremba, S. Meinert, C. Bürger, L. Plümpe, J. Alferink, W. Heindel, H. Kugel, P. Zwanzger, V. Arolt, U. Dannlowski

CCNP News and Views

Advances in understanding and treating mental illness: proceedings of the 40th Canadian College of Neuropsychopharmacology Annual Meeting Symposia
C.P. Normandeau, D. Naumova, S.L. Thompson, M. Ebrahimzadeh, Y.Q. Liu, L. Reynolds, H.-Y. Ren, E.R. Hawken, É.C. Dumont

SSCF/CCNP 2017 graduate studentship for biomedical research in schizophrenia and psychosis

Psychopharmacology for the Clinician

Treating delayed sleep–wake phase disorder in young adults
D.B. Boivin

July 2017

J Psychiatry Neurosci 2017;42(4)


Neuroimaging tests for clinical psychiatry: Are we there yet?
M. Leyton, S.H. Kennedy


Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
L.R. Aleksandrova, A.G. Phillips, Y.T. Wang

Research Papers

Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents
T. Duan, N. Gu, Y. Wang, F. Wang, J. Zhu, Y. Fang, Y. Shen, J. Han, X. Zhang

Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder
N.F. Ho, Z. Li, F. Ji, M. Wang, C.N. Kuswanto, M.Y. Sum, H.Y. Tng, Y.Y. Sitoh, K. Sim, J. Zhou

S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
R. Polimanti, S.A. Meda, G.D. Pearlson, H. Zhao, R. Sherva, L.A. Farrer, H.R. Kranzler, J. Gelernter

Functional MRI examination of empathy for pain in people with schizophrenia reveals abnormal activation related to cognitive perspective-taking but typical activation linked to affective sharing
D. Vistoli, M.-A. Lavoie, S. Sutliff, P.L. Jackson, A.M. Achim

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans
S. Thiebes, G. Leicht, S. Curic, S. Steinmann, N. Polomac, C. Andreou, I. Eichler, L. Eichler, C. Zöllner, J. Gallinat,
I. Hanganu-Opatz, C. Mulert

Psychopharmacology for the Clinician

Recognition and management of antidepressant discontinuation syndrome
V. Bhat, S.H. Kennedy

May 2017

J Psychiatry Neurosci 2017;42(3)


Smoking, psychiatric illness and the brain
P. Boksa

Research Papers

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging
J. Jiang, Y.-J. Zhao, X.-Y. Hu, M.-Y. Du, Z.-Q. Chen, M. Wu, K.-M. Li, H.-Y. Zhu, P. Kumar, Q.-Y. Gong

Accelerated aging of the putamen in patients with major depressive disorder
M.D. Sacchet, M.C. Camacho, E.E. Livermore, E.A.C. Thomas, I.H. Gotlib

Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study
J.J. Shenker, S.M. Sengupta, R. Joober, A. Malla, M.M. Chakravarty, M. Lepage

Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex
M.J. Hill, R. Killick, K. Navarrete, A. Maruszak, G.M. McLaughlin, B.P. Williams, N.J. Bray

Psychobiological response to pain in female adolescents with nonsuicidal self-injury
J. Koenig, L. Rinnewitz, M. Warth, T.K. Hillecke, R. Brunner, F. Resch, M. Kaess

Neural correlates of an attentional bias to health-threatening stimuli in individuals with pathological health anxiety
D. Mier, J. Bailer, J. Ofer, T. Kerstner, V. Zamoscik, F. Rist, M. Witthöft, C. Diener

CCNP News and Views

Canadian College of Neuropsychopharmacology 2017 award winners

Psychopharmacology for the Clinician

Pharmacotherapy of trichotillomania
V. Sharma

March 2017

J Psychiatry Neurosci 2017;42(2)


The gut microbiota and psychiatric illness
G. MacQueen, M. Surette, P. Moayyedi

Research Papers

Abstinence reverses EEG-indexed attention bias between drug-related and pleasant stimuli in cocaine-addicted individuals
M.A. Parvaz, S.J. Moeller, P. Malaker, R. Sinha, N. Alia-Klein, R.Z. Goldstein

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development
O. Gay, M. Plaze, C. Oppenheim, R. Gaillard, J.-P. Olié, M.-O. Krebs, A. Cachia

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume
J.P. Hayes, M.W. Logue, A. Reagan, D. Salat, E.J. Wolf, N. Sadeh, J.M. Spielberg, E. Sperbeck, S.M. Hayes, R.E. McGlinchey, W.P. Milberg, M. Verfaellie, A. Stone, S.A. Schichman, M.W. Miller

Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity symptoms and executive functioning: a population-based pediatric neuroimaging study
S.E. Mous, T. White, R.L. Muetzel, H. El Marroun, J. Rijlaarsdam, T.J.C. Polderman, V.W. Jaddoe, F.C. Verhulst, D. Posthuma, H. Tiemeier

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition
D. van der Meer, C.A. Hartman, D. van Rooij, B. Franke, D.J. Heslenfeld, J. Oosterlaan, S.V. Faraone, J.K. Buitelaar, P.J. Hoekstra

Familial and environmental influences on brain volumes in twins with schizophrenia
M.M. Picchioni, F. Rijsdijk, T. Toulopoulou, C. Chaddock, J.H. Cole, U. Ettinger, A. Oses, H. Metcalfe, R.M. Murray, P. McGuire

Δ9-Tetrahydrocannabinol decreases willingness to exert cognitive effort in male rats
M.M. Silveira, W.K. Adams, M. Morena, M.N. Hill, C.A. Winstanley


Correction: Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia

Psychopharmacology for the Clinician

Generic formulations of psychotropic medications and treatment response
V. Bhat, H.C. Margolese

July 2016


Deconstructing the mental health crisis: 5 uneasy pieces
Z. Merali, H. Anisman

Deconstructing the mental health crisis in only 2 pieces
R. Joober

Research Papers

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers
C. Alquézar, A. de la Encarnación, F. Moreno, A. López de Munain,
Á. Martín-Requero

Cortical thickness, volume and surface area in patients with bipolar disorder types I and II
C. Abé, C.-J. Ekman, C. Sellgren, P. Petrovic, M. Ingvar, M. Landén

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study
T.J. McDermott, A.S. Badura-Brack, K.M. Becker, T.J. Ryan, M.M. Khanna,
E. Heinrichs-Graham, T.W. Wilson

Anomalous basal ganglia connectivity and obsessive–compulsive behaviour in patients with Prader Willi syndrome
J. Pujol, L. Blanco-Hinojo, S. Esteba-Castillo, A. Caixàs, B.J. Harrison,
M. Bueno, J. Deus, M. Rigla, D. Macià, J. Llorente-Onaindia, R. Novell-Alsina

Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
J. Bralten, C.U. Greven, B. Franke, M. Mennes, M.P. Zwiers, N.N.J. Rommelse, C. Hartman, D. van der Meer, L. O’Dwyer, J. Oosterlaan, P.J. Hoekstra, D. Heslenfeld, A. Arias-Vasquez, J.K. Buitelaar

An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive–compulsive disorder
I. van de Vondervoort, G. Poelmans, A. Aschrafi, D.L. Pauls, J.K. Buitelaar, J.C. Glennon, B. Franke

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled study
D.M. Blumberger, J.J. Maller, L. Thomson, B.H. Mulsant, T.K. Rajji,
M. Maher, P.E. Brown, J. Downar, F. Vila-Rodriguez, P.B. Fitzgerald,
Z.J. Daskalakis

Psychopharmacology for the Clinician

Elevated clozapine plasma concentration secondary to a urinary tract infection: proposed mechanisms
L.H.N. Lee, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn