January 2017

J Psychiatry Neurosci 2017;42(1)


The adaptive brain in mental health: overcoming inherited risk factors
P.R. Albert

Research Papers

Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression
S. Njau, S.H. Joshi, R. Espinoza, A.M. Leaver, M. Vasavada, A. Marquina, R.P. Woods, K.L. Narr

Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts
P. Orban, M. Desseilles, A. Mendrek, J. Bourque, P. Bellec, E. Stip

Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder
Z.Y. Sun, J. Houenou, D. Duclap, S. Sarrazin, J. Linke, C. Daban, N. Hamdani, M.-A. d’Albis, P. Le Corvoisier, P. Guevara, M. Delavest, F. Bellivier, J. Almeida, A. Versace, C. Poupon, M. Leboyer, M. Phillips, M. Wessa, J.-F. Mangin

Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice
T.-N. Huang, Y.-P. Hsueh

Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice
M. Didriksen, K. Fejgin, S.R.O. Nilsson, M.R. Birknow, H.M. Grayton, P.H. Larsen, J.B. Lauridsen, V. Nielsen, P. Celada, N. Santana, P. Kallunki, K.V. Christensen, T.M. Werge, T.B. Stensbøl, J. Egebjerg, F. Gastambide, F. Artigas, J.F. Bastlund, J. Nielsen

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease
M.P. Serrano, R. Herrero-Labrador, H.S. Futch, J. Serrano, A. Romero, A.P. Fernandez, A. Samadi, M. Unzeta, J. Marco-Contelles, R. Martínez-Murillo


2016 Reviewers

Psychopharmacology for the Clinician

Refractory social anxiety disorder
M. Van Ameringen, B. Patterson

November 2016

J Psychiatry Neurosci 2016;41(6)


Legal responses to neuroscience
J. Fuss

Research Papers

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis
A. Schmidt, L. Palaniyappan, R. Smieskova, A. Simon, A. Riecher-Rössler, U.E. Lang, P. Fusar-Poli, P. McGuire, S.J. Borgwardt

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa
I. Boehm, D. Geisler, F. Tam, J.A. King, F. Ritschel, M. Seidel, F. Bernardoni, J. Murr, T. Goschke, V.D. Calhoun, V. Roessner, S. Ehrlich

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
S.M. Clark, A. Pocivavsek, J.D. Nicholson, F.M. Notarangelo, P. Langenberg, R.P. McMahon, J.E. Kleinman, T.M. Hyde, J. Stiller, T.T. Postolache, R. Schwarcz, L.H. Tonelli

Male-typical visuospatial functioning in gynephilic girls with gender dysphoria — organizational and activational effects of testosterone
S.M. Burke, B.P.C. Kreukels, P.T. Cohen-Kettenis, D.J. Veltman, D.T. Klink, J. Bakker

COMT and DAT1 genes are associated with hyperactivity and inattention traits in the 1993 Pelotas Birth Cohort: evidence of sex-specific combined effect
G.C. Akutagava-Martins, A. Salatino-Oliveira, C. Kieling, J.P. Genro, G.V. Polanczyk, L. Anselmi, A.M.B. Menezes, H. Gonçalves, F.C. Wehrmeister, F.C. Barros, S.M. Callegari-Jacques, L.A. Rohde, M.H. Hutz

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population
X. Yin, N.E. Wineinger, K. Wang, W. Yue, N. Norgren, L. Wang, W. Yao, X. Jiang, B. Wu, Y. Cui, C. Shen, H. Cheng, F. Zhou, G. Chen, X. Zuo, X. Zheng, X. Fan, H. Wang, L. Wang, J. Lee, M. Lam, E.S. Tai, Z. Zhang, Q. Huang, L. Sun, J. Xu, S. Yang, K.C. Wilhelmsen, J. Liu, N.J. Schork, X. Zhang

The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial
L. Tebartz van Elst, S. Maier, S. Klöppel, E. Graf, C. Killius, M. Rump, E. Sobanski, D. Ebert, M. Berger, A. Warnke, S. Matthies, E. Perlov, A. Philipsen

Psychopharmacology for the Clinician

Clozapine for the management of persistent catatonia
K. Tabbane, S. Halayem, R. Joober

Letters to the Editor

Concepts and misconceptions regarding clinical staging models
J. Shah, J. Scott

Concepts and misconceptions regarding clinical staging models – Author response
M. Alda, F. Kapczinski

September 2016

J Psychiatry Neurosci 2015;41(5)


Staging model raises fundamental questions about the nature of bipolar disorder
M. Alda, F. Kapczinski

Research Papers

Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/ hippocampus and various nodes of the default mode network
W. Regen, S.D. Kyle, C. Nissen, B. Feige, C. Baglioni, J. Hennig, D. Riemann, K. Spiegelhalder

Prediction error and somatosensory insula activation in women recovered from anorexia nervosa
G.K.W. Frank, S. Collier, M.E. Shott, R.C. O’Reilly

Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia
A.R. Mayer, F.M. Hanlon, A.B. Dodd, R.A. Yeo, K.Y. Haaland, J.M. Ling, S.G. Ryman

Cocaine cue–induced dopamine release in the human prefrontal cortex
M.S. Milella, A. Fotros, P. Gravel, K.F. Casey, K. Larcher, J.A.J. Verhaeghe, S.M.L. Cox, A.J. Reader, A. Dagher, C. Benkelfat, M. Leyton

Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders
K.C. Skåtun, T. Kaufmann, S. Tønnesen, G. Biele, I. Melle, I. Agartz, D. Alnæs, O.A. Andreassen, L.T. Westlye

MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
A. Aschrafi, J.M. Verheijen, P.M. Gordebeke, N. F. Olde Loohuis, K. Menting, A. Jager, M. Palkovits, B. Geenen, A. Kos, G.J.M. Martens, J.C. Glennon, B.B. Kaplan, B. Gaszner, T. Kozicz

Neural signature of behavioural inhibition in women with bulimia nervosa
M. Skunde, S. Walther, J.J. Simon, M. Wu, M. Bendszus, W. Herzog, H.-C. Friederich

Psychopharmacology for the Clinician

Managing the comorbidity of schizophrenia and ADHD
A. Gough, J. Morrison

May 2016


Dynamic endophenotypes and longitudinal trajectories: capturing changing aspects of development in early psychosis
J.L. Shah, M.M. Chakravarty, R. Joober, M. Lepage

Research Papers

Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia
M. Kirschner, O.M. Hager, M. Bischof, M.N. Hartmann, A. Kluge, E. Seifritz, P.N. Tobler, S. Kaiser

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study
T.T. van Sloten, G.F. Mitchell, S. Sigurdsson, M.A. van Buchem, P.V. Jonsson, M.E. Garcia, T.B. Harris, R.M.A. Henry, A.S. Levey, C.D.A. Stehouwer, V. Gudnason, L.J. Launer

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour
E. Isingrini, L. Perret, Q. Rainer, S. Sagueby, L. Moquin, A. Gratton, B. Giros

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study
C. Binelli, A. Muñiz, S. Subira, R. Navines, L. Blanco-Hinojo, D. Perez-Garcia, J. Crippa, M. Farré, L. Pérez-Jurado, J. Pujol, R. Martin-Santos

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
D. Stacey, A. Lourdusamy, B. Ruggeri, M. Maroteaux, T. Jia, A. Cattrell, C. Nymberg, T. Banaschewski, S. Bhattacharyya, H. Band, G. Barker, A. Bokde, C. Buchel, F. Carvalho, P. Conrod, S. Desrivieres, A. Easton, M. Fauth-Buehler, A. Fernandez-Medarde, H. Flor, V. Frouin, J. Gallinat, H. Garavanh, A. Heinz, B. Ittermann, M. Lathrop, C. Lawrence, E. Loth, K. Mann, J.-L. Martinot, F. Nees, T. Paus, Z. Pausova, M. Rietschel, A. Rotter, E. Santos, M. Smolka, W. Sommer, M. Mameli, R. Spanagel, J.-A. Girault, C. Mueller, G. Schumann; on behalf of the IMAGEN consortium

The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety
J.A. Scott, N. Goodrich-Hunsaker, K. Kalish, A. Lee, M.R. Hunsaker, C.M. Schumann, O.T. Carmichael, T.J. Simon

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men
H. Stuke, S. Gutwinski, C.E. Wiers, T.T. Schmidt, S. Gröpper, J. Parnack, C. Gawron, C.H. Attar, S. Spengler, H. Walter, A. Heinz, F. Bermpohl

Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy
M.J. Dubin, X. Mao, S. Banerjee, Z. Goodman, K.A.B. Lapidus, G. Kang, C. Liston, D.C. Shungu

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia
B. García-Bueno, P. Gassó, K.S. MacDowell, L.F. Callado, S. Mas, M. Bernardo, A. Lafuente, J.J. Meana, J.C. Leza

CCNP News and Views

Canadian College of Neuropsychopharmacology 2015 award winners

Psychopharmacology for the Clinician

Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
R.M. Procyshyn, J.L. Banasch, A.M. Barr, W.G. Honer

March 2016

J Psychiatry Neurosci 2016;41(2)


Legalizing marijuana
M. Leyton

Research Papers

Reduced error signalling in medication-naive children with ADHD: associations with behavioural variability and post-error adaptations
K.J. Plessen, E.A. Allen, H. Eichele, H. van Wageningen, M. Farstad Høvik, L. Sørensen, M. Kalsås Worren, K. Hugdahl, T. Eichele

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis
G.A. Alvares, D.S. Quintana, I.B. Hickie, A.J. Guastella

Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study
F. Bouckaert, F.-L. De Winter, L. Emsell, A. Dols, D. Rhebergen, M. Wampers, S. Sunaert, M. Stek, P. Sienaert, M. Vandenbulcke

Structural covariance of neostriatal and limbic regions in patients with obsessive–compulsive disorder
M. Subirà, M. Cano, S.J. de Wit, P. Alonso, N. Cardoner, M.Q. Hoexter, J.S. Kwon, T. Nakamae, C. Lochner, J.R. Sato, W.H. Jung, J. Narumoto, D.J. Stein, J. Pujol, D. Mataix-Cols, D.J. Veltman, OCD Brain Imaging Consortium, J.M. Menchón, O.A. van den Heuvel, C. Soriano-Mas

Identification of segregated regions in the functional brain connectome of autistic patients by a combination of fuzzy spectral clustering and entropy analysis
J.R. Sato, J. Balardin, M.C. Vidal, A. Fujita

Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade
B.H. Ebdrup, J.M. Raghava, M.Ø. Nielsen, E. Rostrup, B. Glenthøj

Aberrant network connectivity during error processing in patients with schizophrenia
R. Voegler, M.P.I. Becker, A. Nitsch, W.H.R. Miltner, T. Straube 

Eye-tracking reveals a slowdown of social context processing during intention attribution in patients with schizophrenia
P. Roux, E. Brunet-Gouet, C. Passerieux, F. Ramus

Psychopharmacology for the Clinician

Treating comorbid premenstrual dysphoric disorder in women with bipolar disorder
M. Smith, B.N. Frey

Letters to the Editor

Smoking as a confounder of the association of suicidality with serum lipid levels
I. Berlin, A. Luquiens, H. Aubin

Smoking as a confounder of the association of suicidality with serum lipid levels – Author response
S. Wu, J. Hou, P. Mao

January 2016

J Psychiatry Neurosci 2016;41(1)


Neurolaw: recognizing opportunities and challenges for psychiatry
G. Meynen

Research Papers

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa
D. Geisler, V. Borchardt, A.R. Lord, I. Boehm, F. Ritschel, J. Zwipp, S. Clas, J.A. King, S. Wolff-Stephan, V. Roessner, M. Walter, S. Ehrlich

Time course of facial emotion processing in women with borderline personality disorder: an ERP study
N.A. Izurieta Hidalgo, R. Oelkers-Ax, K. Nagy, F. Mancke, M. Bohus, S.C. Herpertz, K. Bertsch

Potential serum biomarkers from a metabolomics study of autism
H. Wang, S. Liang, M. Wang, J. Gao, C. Sun, J. Wang, W. Xia, S. Wu, S.J. Sumner, F. Zhang, C. Sun, L. Wu

Healthy co-twins of patients with affective disorders show reduced risk-related activation of the insula during a monetary gambling task
J. Macoveanu, K. Miskowiak, L.V. Kessing, M. Vinberg, H.R. Siebner

Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers
K.J. Hartwell, C.A. Hanlon, X. Li, J.J. Borckardt, M. Canterberry, J.J. Prisciandaro, M.M. Moran-Santa Maria, T. LeMatty, M.S. George, K.T. Brady

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies
S. Wu, Y. Ding, F. Wu, G. Xie, J. Hou, P. Mao


2015 Reviewers

Psychopharmacology for the Clinician

Successful management of clozapine adverse effects with extended (alternate day) antipsychotic dosing in a patient with schizophrenia
V. Kumar, L. Sharma, S. Madival, G. Venkatasubramanian

November 2015

J Psychiatry Neurosci 2015;40(6)


Mental wellness in Canada’s Aboriginal communities: striving toward reconciliation
P. Boksa, R. Joober, L.J. Kirmayer

Research Papers

Sex differences in conditioned stimulus discrimination during context-dependent fear learning and its retrieval in humans: the role of biological sex, contraceptives and menstrual cycle phases
T.B. Lonsdorf, J. Haaker, D. Schümann, T. Sommer, J. Bayer, S. Brassen, N. Bunzeck, M. Gamer, R. Kalisch

Cognitive effects of deep brain stimulation in patients with obsessive–compulsive disorder
M. Mantione, D. Nieman, M. Figee, P. van den Munckhof, R. Schuurman, D. Denys

Olfactory performance segregates effects of anhedonia and anxiety on social function in patients with schizophrenia
K. Cieslak, J. Walsh-Messinger, A. Stanford, L. Vaez-Azizi, D. Antonius, J. Harkavy-Friedman, D. Goetz, R.R. Goetz, D. Malaspina

Valence and agency influence striatal response to feedback in patients with major depressive disorder
J. Späti, J. Chumbley, N. Doerig, J. Brakowski, M. Grosse Holtforth, E. Seifritz, S. Spinelli

Voxel-wise meta-analyses of brain blood flow and local synchrony abnormalities in medication-free patients with major depressive disorder
Z.-Q. Chen, M.-Y. Du, Y.-J. Zhao, X.-Q. Huang, J. Li, S. Lui, J.-M. Hu, H.-Q. Sun, J. Liu, G.J. Kemp, Q.-Y. Gong

Baseline brain perfusion and brain structure in patients with major depression: a multimodal magnetic resonance imaging study
N. Vasic, N.D. Wolf, G. Grön, Z. Sosic-Vasic, B.J. Connemann,
F. Sambataro, A. von Strombeck, D. Lang, S. Otte, M. Dudek, R.C. Wolf

Dopamine effects on evidence gathering and integration
C. Andreou, B.C. Schneider, V. Braun, K. Kolbeck, J. Gallinat, S. Moritz


Deep brain stimulation to reduce sexual drive
J. Fuss, M.K. Auer, S.V. Biedermann, P. Briken, W. Hacke


Adolescence as a unique developmental period


Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania

Psychopharmacology for the Clinician

Treatment-resistant depression in later life
H. El Bayoumi, Z. Ismail

Online Letter to the Editor

Exit exceptionalism: mental disease is like any other medical disease
B. Hofmann

Exit exceptionalism: mental disease is like any other medical disease – Author response
A. Malla, R. Joober, A. Garcia

September 2015

J Psychiatry Neurosci 2015;40(5)


Adolescence as a unique developmental period
N. Jaworska, G. MacQueen

Research Papers

DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli
T. Frodl, M. Szyf, A. Carballedo, V. Ly, S. Dymov, F. Vaisheva, D. Morris, C. Fahey, J. Meaney, M. Gill, L. Booij

Elevated cognitive control over reward processing in recovered female patients with anorexia nervosa
S. Ehrlich, D. Geisler, F. Ritschel, J.A. King, M. Seidel, I. Boehm, M. Breier, S. Clas, J. Weiss, M. Marxen, M.N. Smolka, V. Roessner, N.B. Kroemer

Using structural MRI to identify individuals at genetic risk for bipolar disorders: a 2-cohort, machine learning study
T. Hajek, C. Cooke, M. Kopecek, T. Novak, C. Hoschl, M. Alda

Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/ hyperactivity disorder
H.-L. Chiang, Y.-J. Chen, Y.-C. Lo, W.-Y.I. Tseng, S.S.-F. Gau

Childhood abuse and neglect may induce deficits in cognitive precursors of psychosis in high-risk children
N. Berthelot, T. Paccalet, E. Gilbert, I. Moreau, C. Mérette, N. Gingras, N. Rouleau, M. Maziade

Lower white matter microstructure in the superior longitudinal fasciculus is associated with increased response time variability in adults with attention-deficit/ hyperactivity disorder
T. Wolfers, A.M.H. Onnink, M.P. Zwiers, A. Arias-Vasquez, M. Hoogman, J.C. Mostert, C.C. Kan, D. Slaats-Willemse, J.K. Buitelaar, B. Franke

Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study
S. Sarrazin, M.-A. d’Albis, C. McDonald, J. Linke, M. Wessa, M. Phillips, M. Delavest, L. Emsell, A. Versace, J. Almeida, J.-F. Mangin, C. Poupon, K. Le Dudal, C. Daban, N. Hamdani, M. Leboyer, J. Houenou

Psychopharmacology for the Clinician

Topiramate augmentation in a patient with obsessive–compulsive disorder
M. Van Ameringen, B. Patterson

Online Letters to the Editor

Altered pain threshold sensitivity and frontoparietal–cingulate network in anorexia nervosa: the role of disgust sensitivity
C. Vicario

Altered pain threshold sensitivity and frontoparietal–cingulate network in anorexia nervosa: the role of disgust sensitivity – Author response
K. Bär, G. Wagner

July 2015

J Psychiatry Neurosci 2015;40(4)


Why is depression more prevalent in women?
P.R. Albert

Research Papers

A randomized double-blind crossover trial of deep brain stimulation of the subcallosal cingulate gyrus in patients with treatment-resistant depression: a pilot study of relapse prevention
D. Puigdemont, M.J. Portella, R. Pérez-Egea, J. Molet, A. Gironell, J. de Diego-Adeliño, A. Martín, R. Rodríguez, E. Àlvarez, F. Artigas, V. Pérez

Brain structural correlates of sensory phenomena in patients with obsessive–compulsive disorder
M. Subirà, J.R. Sato, P. Alonso, M.C. do Rosário, C. Segalàs, M.C. Batistuzzo, E. Real, A.C. Lopes, E. Cerrillo, J.B. Diniz, J. Pujol, R.O. Assis, J.M. Menchón, R.G. Shavitt, G.F. Busatto, N. Cardoner, E.C. Miguel, M.Q. Hoexter, C. Soriano-Mas

Cigarette smoking is associated with thinner cingulate and insular cortices in patients with severe mental illness
K.N. Jørgensen, I. Skjærvø, L. Mørch-Johnsen, U.K. Haukvik, E. Heffermehl Lange, I. Melle, O.A. Andreassen, I. Agartz

Monocyte and microglial activation in patients with mood-stabilized bipolar disorder
J. Jakobsson, M. Bjerke, S. Sahebi, A. Isgren, C.J. Ekman, C. Sellgren, B. Olsson, H. Zetterberg, K. Blennow, E. Pålsson, M. Landén

A significant risk factor for poststroke depression: the depression-related subnetwork
S. Yang, P. Hua, X. Shang, Z. Cui, S. Zhong, G. Gong, G.W. Humphreys

Structural and functional differences in the cingulate cortex relate to disease severity in anorexia nervosa
K.-J. Bär, F. de la Cruz, S. Berger, C.C. Schultz, G. Wagner

Microstructural abnormalities of the brain white matter in attention-deficit/hyperactivity disorder
L. Chen, X. Huang, D. Lei, N. He, X. Hu, Y. Chen, Y. Li, J. Zhou, L. Guo, G.J. Kemp, Q. Gong

Psychopharmacology for the Clinician

Acute renal and neurotoxicity in older lithium users: How can we manage and prevent these events in patients with late-life mood disorders?
V. Laliberté, C. Yu, S. Rej

May 2015


“Mental illness is like any other medical illness”: a critical examination of the statement and its impact on patient care and society
A. Malla, R. Joober, A. Garcia

Research Papers

Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline
S. Gourmaud, C. Paquet, J. Dumurgier, C. Pace, C. Bouras, F. Gray, J.-L. Laplanche, E.F. Meurs, F. Mouton-Liger, J. Hugon

Reduced activation in the ventral striatum during probabilistic decision-making in patients in an at-risk mental state
F. Rausch, D. Mier, S. Eifler, S. Fenske, F. Schirmbeck, S. Englisch, C. Schilling,  A. Meyer-Lindenberg, P. Kirsch, M. Zink

Vortioxetine: a meta-analysis of 12 short-term, randomized, placebo-controlled clinical trials for the treatment of major depressive disorder
C.-U. Pae, S.-M. Wang, C. Han, S.-J. Lee, A.A. Patkar, P.S. Masand, A. Serretti

The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study
B. Gutiérrez, J.A. Bellón, M. Rivera, E. Molina, M. King, L. Marston, F. Torres-González, B. Moreno-Küstner, P. Moreno-Peral, E. Motrico, C. Montón-Franco, M.J. GildeGómez-Barragán, M. Sánchez-Celaya, M.A. Díaz-Barreiros, C. Vicens, J. de Dios Luna, I. Nazareth, J. Cervilla

Brain volume in male patients with recent onset schizophrenia with and without cannabis use disorders
L. Koenders, M.W.J. Machielsen,  F.J. van der Meer, A.C.M. van Gasselt, C.J. Meijer, W. van den Brink, M.W.J. Koeter, M.W.A. Caan, J. Cousijn, A. den Braber, D. van ‘t Ent, M.M. Rive, A.H. Schene, E. van de Giessen, C. Huyser, B.P. de Kwaasteniet, D.J. Veltman, L. de Haan

Grey matter, an endophenotype for schizophrenia? A voxel-based morphometry study in siblings of patients with schizophrenia
J. van der Velde, P.M. Gromann, M. Swart, L. de Haan, D. Wiersma, R. Bruggeman, L. Krabbendam, A. Aleman

CCNP News and Views

Obituary of Theodore L. Sourkes, PhD, FRSC, OC

Canadian College of Neuropsychopharmacology 2015 award winners


Correction – Impaired musical ability in people with schizophrenia

Psychopharmacology for the Clinician

Inappropriate benzodiazepine use in elderly patients and its reduction
C. Tannenbaum

March 2015

J Psychiatry Neurosci 2015;40(2)


Can the neurodevelopmental theory account for sex differences in schizophrenia across the life span?
C.H. Baldwin, L.K. Srivastava

Research Papers

Knockdown of phospholipase C-β1 in the medial prefrontal cortex of male mice impairs working memory among multiple schizophrenia endophenotypes
S.-W. Kim, M. Seo, D.-S. Kim, M. Kang, Y.-S. Kim, H.-Y. Koh, H.-S. Shin

Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia
F. Schirmbeck, D. Mier, C. Esslinger, F. Rausch, S. Englisch, S. Eifler, A. Meyer-Lindenberg, P. Kirsch, M. Zink

Does neuroanatomy account for superior temporal dysfunction in early psychosis? A multimodal MRI investigation
W. Pettersson-Yeo, S. Benetti, S. Frisciata, M. Catani, S.C.R. Williams, P. Allen, P. McGuire, A. Mechelli

Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats
M.M. Barrus, J.G. Hosking, F.D. Zeeb, M. Tremblay, C.A. Winstanley

An eye-tracking investigation of intentional motion perception in patients with schizophrenia
P. Roux, C. Passerieux, F. Ramus

Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia — significance for activation of the kynurenine pathway
L. Schwieler, M.K. Larsson, E. Skogh, M.E. Kegel, F. Orhan, S. Abdelmoaty, A. Finn, M. Bhat, M. Samuelsson, K. Lundberg, M.-L. Dahl, C. Sellgren, I. Schuppe-Koistinen, C.I. Svensson, S. Erhardt, G. Engberg

Sad mood induction has an opposite effect on amygdala response to emotional stimuli in euthymic patients with bipolar disorder and healthy controls
J. Horacek, P. Mikolas, J. Tintera, T. Novak, T. Palenicek, M. Brunovsky, C. Höschl, M. Alda

Psychopharmacology for the Clinician

Adjunctive treatment with melatonin receptor agonists for older delirious patients with the sundowning phenomenon
T.-C. Yeh, C.-B. Yeh, N.-S. Tzeng, W.-C. Mao

January 2015

J Psychiatry Neurosci 2015;40(1)


On telomeres long and short
N. Corbett, M. Alda

Review Papers

Genetic and early environmental influences on the serotonin system: consequences for brain development and risk for psychopathology
L. Booij, R.E. Tremblay, M. Szyf, C. Benkelfat

Neurophysiological effects of acute oxytocin administration: systematic review and meta-analysis of placebo-controlled imaging studies
R. Wigton, J. Radua, P. Allen, B. Averbeck, A. Meyer-Lindenberg, P. McGuire, S.S. Shergill, P. Fusar-Poli

Research Papers

Grey matter alterations in patients with depersonalization disorder: a voxel-based morphometry study
J.K. Daniels, M. Gaebler, J.-P. Lamke, H. Walter

Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders
R. Robillard, D.F. Hermens, S.L. Naismith, D. White, N.L. Rogers, T.K.C. Ip, S.J. Mullin, G.A. Alvares, A.J. Guastella, K.L. Smith, Y. Rong, B. Whitwell, J. Southan, N. Glozier, E.M. Scott, I.B. Hickie

Prenatal exposure to cigarette smoke interacts with OPRM1 to modulate dietary preference for fat
K.W.K. Lee, M. Abrahamowicz, G.T. Leonard, L. Richer, M. Perron, S. Veillette, E. Reischl, L. Bouchard, D. Gaudet, T. Paus, Z. Pausova

Functional dysconnectivity of corticostriatal circuitry and differential response to methylphenidate in youth with attention-deficit/hyperactivity disorder
S.-B. Hong,  B.J. Harrison,  A. Fornito, C.-H. Sohn, I.-C. Song,  J.-W. Kim

Shared intermediate phenotypes for schizophrenia and bipolar disorder: neuroanatomical features of subtypes distinguished by executive dysfunction
A.M. Shepherd, Y. Quidé, K.R. Laurens, N. O’Reilly, J.E. Rowland, P.B. Mitchell, V.J. Carr, M.J. Green


2014 Reviewers

Psychopharmacology for the Clinician

Add-on lithium for the treatment of unipolar depression: Too often forgotten?
F. Jollant

November 2014

J Psychiatry Neurosci 2014;39(6)


Gut feelings about depression
A. Abizaid, H. Anisman

Research Papers

Disruption of brain white matter microstructure in women with anorexia nervosa
E. Via, A. Zalesky, I. Sánchez, L. Forcano, B.J. Harrison, J. Pujol, F. Fernández-Aranda, J.M. Menchón, C. Soriano-Mas, N. Cardoner, A. Fornito

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder
C. Hercher, V. Chopra, C.L. Beasley

Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia
A.J. Forstner, F.B. Basmanav, M. Mattheisen, GROUP Investigators, A.C. Böhmer, M.V. Hollegaard, E. Janson, E. Strengman, L. Priebe, F. Degenhardt, P. Hoffmann, S. Herms, W. Maier, R. Mössner, D. Rujescu, R.A. Ophoff, S. Moebus, P.B. Mortensen, A.D. Børglum, D.M. Hougaard, J. Frank, S.H. Witt, M. Rietschel, A. Zimmer, M.M. Nöthen, X. Miró, S. Cichon

Brain grey matter volume alterations in late-life depression
M. Du, J. Liu, Z. Chen, X. Huang, J. Li, W. Kuang, Y. Yang, W. Zhang, D. Zhou, F. Bi, K.M. Kendrick, Q. Gong

Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics
N. Matosin, F. Fernandez-Enright, E. Frank, C. Deng, J. Wong, X.-F. Huang, K.A. Newell

White matter tractography in early psychosis: clinical and neurocognitive associations
S.N. Hatton, J. Lagopoulos, D.F. Hermens, I.B. Hickie, E. Scott, M.R. Bennett

Psychopharmacology for the Clinician

Clozapine augmentation with amisulpride
S. Porcelli, A. Serretti, O. Bianchini

September 2014

J Psychiatry Neurosci 2014;39(5)


What’s deficient in reward deficiency?
M. Leyton

Research Papers

Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism
A. Anitha, I. Thanseem, K. Nakamura, M.M. Vasu, K. Yamada, T. Ueki, Y. Iwayama, T. Toyota, K.J. Tsuchiya, Y. Iwata, K. Suzuki, T. Sugiyama, M. Tsujii, T. Yoshikawa, N. Mori

Resting-state functional connectivity abnormalities in patients with obsessive–compulsive disorder and their healthy first-degree relatives
J.-M. Hou, M. Zhao, W. Zhang, L.-H. Song, W.-J. Wu, J. Wang,
D.-Q. Zhou, B. Xie, M. He, J.-W. Guo, W. Qu, H.-T. Li

MicroRNA-137 regulates a glucocorticoid receptor–dependent signalling network: implications for the etiology of schizophrenia
A. Vallès, G.J.M. Martens, P. De Weerd, G. Poelmans, A. Aschrafi

Sustained anxiety increases amygdala–dorsomedial prefrontal coupling: a mechanism for maintaining an anxious state in healthy adults
K.E. Vytal, C. Overstreet, D.R. Charney, O.J. Robinson, C. Grillon

Impaired right inferior frontal gyrus response to contextual cues in male veterans with PTSD during response inhibition
S.J.H. van Rooij, A.R. Rademaker, M. Kennis, M. Vink, R.S. Kahn, E. Geuze

Do reward-processing deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of physiological response to natural rewards and drug cues
C.M. Cassidy, M.B. Brodeur, M. Lepage, A. Malla

BDNF–ERK–CRE Bsignalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice
L.-T. Yi, J. Li, B.-B. Liu, L. Luo, Q. Liu, D. Geng

Psychopharmacology for the Clinician

Major depressive disorder and cognitive impairment
R.S. McIntyre

July 2014

J Psychiatry Neurosci 2014;39(4)


Medium range cognitive impairment (MeRCI) hypothesis for psychosis formation: evidence from epidemiological studies and recent molecular genetic developments
R. Joober

Review Paper

Antipsychotic dosing: found in translation
G. Remington, G. Fervaha, G. Foussias, O. Agid, P. Turrone

Research Papers

Enhanced corticobulbar excitability in chronic smokers during visual exposure to cigarette smoking cues
C.M. Vicario, N. Komeilipoor, P. Cesari, R.D. Rafal, M.A. Nitsche

Abnormal effective connectivity and psychopathological symptoms in the psychosis high-risk state
A. Schmidt, R. Smieskova, A. Simon, P. Allen, P. Fusar-Poli, P.K. McGuire, K. Bendfeldt, J. Aston, U.E. Lang, M. Walter, E.-W. Radue, A. Riecher-Rössler, S.J. Borgwardt

Behavioural and neural correlates of self-focused emotion regulation in social anxiety disorder
M. Gaebler, J.K. Daniels, J.-P. Lamke, T. Fydrich, H. Walter

Neuron-specific Sumo1–3 knockdown in mice impairs episodic and fear memories
L. Wang, R.M. Rodriguiz, W.C. Wetsel, H. Sheng, S. Zhao, X. Liu,
W. Paschen, W. Yang

Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women
T. Outhred, P. Das, K.L. Felmingham, R.A. Bryant, P.J. Nathan,
G.S. Malhi, A.H. Kemp

Oxidation and nitration in dopaminergic areas of the prefrontal cortex from patients with bipolar disorder and schizophrenia
H.K. Kim, A.C. Andreazza, P.Y. Yeung, C. Isaacs-Trepanier,
L.T. Young

Psychopharmacology for the Clinician

The treatment of bipolar patients with elevated impulsivity and suicide risk
M.E. Sloan, A. Iskric, N.C. Low