May 2018

J Psychiatry Neurosci 2018;43(3)


Drug coverage in Canada: gaps and opportunities
F. Clement, K.A. Memedovich

Research Papers

Altered cortical thickness and attentional deficits in adolescent girls and women with bulimia nervosa
L.A. Berner, M. Stefan, S. Lee, Z. Wang, K. Terranova, E. Attia, R. Marsh

Neural correlates of emotional action control in anger-prone women with borderline personality disorder
K. Bertsch, K. Roelofs, P.J. Roch, B. Ma, S. Hensel, S.C. Herpertz, I. Volman

Assessing the marks of change: how psychotherapy alters the brain structure in women with borderline personality disorder
F. Mancke, R. Schmitt, D. Winter, I. Niedtfeld, S.C. Herpertz, C. Schmahl

A putative electrophysiological biomarker of auditory sensory memory encoding is sensitive to pharmacological alterations of excitatory/inhibitory balance in male macaque monkeys
W.B. Holliday, K. Gurnsey, R.A. Sweet, T. Teichert

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis
Y. Tomioka, S. Numata, M. Kinoshita, H. Umehara, S. Watanabe, M. Nakataki, Y. Iwayama, T. Toyota, M. Ikeda, H. Yamamori, S. Shimodera, A. Tajima, R. Hashimoto, N. Iwata, T. Yoshikawa, T. Ohmori

Neuroanatomical phenotypes in mental illness: identifying convergent and divergent cortical phenotypes across autism, ADHD and schizophrenia
M.T.M. Park, A. Raznahan, P. Shaw, N. Gogtay, J.P. Lerch, M.M. Chakravarty

CCNP News and Views

Canadian College of Neuropsychopharmacology 2018 award winners

Psychopharmacology for the Clinician

Dispensary cannabidiol marijuana and first-episode mania
Z. Ismail

March 2018

J Psychiatry Neurosci 2018;43(2)


Is poststroke depression the same as major depression?
P.R. Albert

Research Papers

Grey matter correlates of autistic traits in women with anorexia nervosa
M. Björnsdotter, M. Davidovic, L. Karjalainen, G. Starck, H. Olausson, E. Wentz

Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex
P. Prini, F. Rusconi, E. Zamberletti, M. Gabaglio, F. Penna, M. Fasano, E. Battaglioli, D. Parolaro, T. Rubino

A postmortem analysis of NMDA ionotropic and group 1 metabotropic glutamate receptors in the nucleus accumbens in schizophrenia
J.S. Lum, S.J. Millard, X.-F. Huang, L. Ooi, K.A. Newell

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study
V. Onete, R.M. Henry, S.J.S. Sep, A. Koster, C.J. van der Kallen, P.C. Dagnelie, N. Schaper, S. Köhler, K. Reesink, C.D.A. Stehouwer, M.T. Schram

Greater body mass index is associated with reduced frontal cortical volumes among adolescents with bipolar disorder
A.H. Islam, A.W.S. Metcalfe, B.J. MacIntosh, D.J. Korczak, B.I. Goldstein

Association between structural and functional brain alterations in drug-free patients with schizophrenia: a multimodal meta-analysis
X. Gao, W. Zhang, L. Yao, Y. Xiao, L. Liu, J. Liu, S. Li, B. Tao, C. Shah, Q. Gong, J.A. Sweeney, S. Lui

Psychopharmacology for the Clinician

Covert dysphagia and recurrent pneumonia related to antipsychotic treatment
J.T. Stewart

January 2018

J Psychiatry Neurosci 2018;43(1)


Culture as an ingredient of personalized medicine
K. Matheson, A. Bombay, H. Anisman

Review Paper

Mindfulness-based treatments for posttraumatic stress disorder: a review of the treatment literature and neurobiological evidence
J.E. Boyd, R.A. Lanius, M.C. McKinnon

Research Papers

Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder
K. Feldker, C.Y. Heitmann, P. Neumeister, L. Brinkmann, M. Bruchmann, P. Zwitserlood, T. Straube

Always on guard: emotion regulation in women with borderline personality disorder compared to nonpatient controls and patients with cluster-C personality disorder
L. van Zutphen, N. Siep, G.A. Jacob, G. Domes, A. Sprenger, B. Willenborg, R. Goebel, A. Arntz

Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men
Q. Li, J. Liu, W. Wang, Y. Wang, W. Li, J. Chen, J. Zhu, X. Yan, Y. Li, Z. Li, J. Ye, W. Wang

Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression
B. Romeo, W. Choucha, P. Fossati, J-Y. Rotge


2017 Reviewers

Psychopharmacology for the Clinician

Pharmacological management of neuropsychiatric symptoms in patients with major neurocognitive disorders
D. Elie, S. Rej

Clozapine, elevated heart rate and QTc prolongation
D.D. Kim, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn

November 2017

J Psychiatry Neurosci 2017;42(6)


The value of a skeptical approach to neurosciences in psychiatric training and practice
A. Traicu, R. Joober

Research Papers

Intranetwork and internetwork connectivity in patients with Alzheimer disease and the association with cerebrospinal fluid biomarker levels
M. Weiler, B. Machado de Campos, C. Vieira de Ligo Teixeira, R.F. Casseb, A.F. Mac Knight Carletti-Cassani, J.E. Vicentini, T.N. Cardoso Magalhães, L.L. Talib, O.V. Forlenza, M.L. Figueredo Balthazar

Basolateral amygdala–ventromedial prefrontal cortex connectivity predicts cognitive behavioural therapy outcome in adults with obsessive–compulsive disorder
M.A. Fullana, X. Zhu, P. Alonso, N. Cardoner, E. Real, C. López-Solà, C. Segalàs, M. Subirà, H. Galfalvy, J.M. Menchón, H.B. Simpson, R. Marsh, C. Soriano-Mas

Refinement by integration: aggregated effects of multimodal imaging markers on adult ADHD
T. Wolfers, A.L. Arenas, A.M.H. Onnink, J. Dammers, M. Hoogman, M.P. Zwiers, J.K. Buitelaar, B. Franke, A.F. Marquand, C.F. Beckmann

Structural alterations in patients with obsessive–compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness
O.G. Rus, T.J. Reess, G. Wagner, M. Zaudig, C. Zimmer, K. Koch

Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder
F.D. Zeeb, Z. Li, D.C. Fisher, M.H. Zack, P.J. Fletcher

Altered intrinsic functional brain architecture in female patients with bulimia nervosa
L. Wang, Q.-M. Kong, K. Li, X.-N. Li, Y.-W. Zeng, C. Chen, Y. Qian, S.-J. Feng, J.-T. Li, Y. Su, C.U. Correll, P.B. Mitchell, C.-G. Yan, D.-R. Zhang, T.-M. Si

In male rats, the ability of central insulin to suppress glucose production is impaired by olanzapine, whereas glucose uptake is left intact
C. Kowalchuk, C. Teo, V. Wilson, A. Chintoh, L. Lam, S.M. Agarwal, A. Giacca, G.J. Remington, M.K. Hahn

Psychopharmacology for the Clinician

Treatment of ADHD in patients with bipolar disorder
R. Girard, R. Joober

September 2017

J Psychiatry Neurosci 2017;42(5)


Psychiatric genetics — Does diagnosis matter?
M. Alda


The neurobiology of transition to psychosis: clearing the cache
L. Palaniyappan, T. Das, K. Dempster

OCD: obsessive–compulsive … disgust? The role of disgust in obsessive–compulsive disorder
T. Bhikram, E. Abi-Jaoude, P. Sandor

Research Papers

Age-related brain structural alterations as an intermediate phenotype of psychosis
J. Dukart, R. Smieskova, F. Harrisberger, C. Lenz, A. Schmidt, A. Walter, C. Huber, A. Riecher-Rössler, A. Simon, U.E. Lang, P. Fusar-Poli, S. Borgwardt

Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients
I.K. Wium-Andersen, M.K. Wium-Andersen, M.B. Jørgensen, M. Osler

Decreased uncinate fasciculus tract integrity in male and female patients with PTSD: a diffusion tensor imaging study
S.B.J. Koch, M. van Zuiden, L. Nawijn, J.L. Frijling, D.J. Veltman, M. Olff

Prefrontal brain responsiveness to negative stimuli distinguishes familial risk for major depression from acute disorder
N. Opel, R. Redlich, D. Grotegerd, K. Dohm, D. Zaremba, S. Meinert, C. Bürger, L. Plümpe, J. Alferink, W. Heindel, H. Kugel, P. Zwanzger, V. Arolt, U. Dannlowski

CCNP News and Views

Advances in understanding and treating mental illness: proceedings of the 40th Canadian College of Neuropsychopharmacology Annual Meeting Symposia
C.P. Normandeau, D. Naumova, S.L. Thompson, M. Ebrahimzadeh, Y.Q. Liu, L. Reynolds, H.-Y. Ren, E.R. Hawken, É.C. Dumont

SSCF/CCNP 2017 graduate studentship for biomedical research in schizophrenia and psychosis

Psychopharmacology for the Clinician

Treating delayed sleep–wake phase disorder in young adults
D.B. Boivin

July 2017

J Psychiatry Neurosci 2017;42(4)


Neuroimaging tests for clinical psychiatry: Are we there yet?
M. Leyton, S.H. Kennedy


Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
L.R. Aleksandrova, A.G. Phillips, Y.T. Wang

Research Papers

Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents
T. Duan, N. Gu, Y. Wang, F. Wang, J. Zhu, Y. Fang, Y. Shen, J. Han, X. Zhang

Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder
N.F. Ho, Z. Li, F. Ji, M. Wang, C.N. Kuswanto, M.Y. Sum, H.Y. Tng, Y.Y. Sitoh, K. Sim, J. Zhou

S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
R. Polimanti, S.A. Meda, G.D. Pearlson, H. Zhao, R. Sherva, L.A. Farrer, H.R. Kranzler, J. Gelernter

Functional MRI examination of empathy for pain in people with schizophrenia reveals abnormal activation related to cognitive perspective-taking but typical activation linked to affective sharing
D. Vistoli, M.-A. Lavoie, S. Sutliff, P.L. Jackson, A.M. Achim

Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans
S. Thiebes, G. Leicht, S. Curic, S. Steinmann, N. Polomac, C. Andreou, I. Eichler, L. Eichler, C. Zöllner, J. Gallinat,
I. Hanganu-Opatz, C. Mulert

Psychopharmacology for the Clinician

Recognition and management of antidepressant discontinuation syndrome
V. Bhat, S.H. Kennedy

May 2017

J Psychiatry Neurosci 2017;42(3)


Smoking, psychiatric illness and the brain
P. Boksa

Research Papers

Microstructural brain abnormalities in medication-free patients with major depressive disorder: a systematic review and meta-analysis of diffusion tensor imaging
J. Jiang, Y.-J. Zhao, X.-Y. Hu, M.-Y. Du, Z.-Q. Chen, M. Wu, K.-M. Li, H.-Y. Zhu, P. Kumar, Q.-Y. Gong

Accelerated aging of the putamen in patients with major depressive disorder
M.D. Sacchet, M.C. Camacho, E.E. Livermore, E.A.C. Thomas, I.H. Gotlib

Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study
J.J. Shenker, S.M. Sengupta, R. Joober, A. Malla, M.M. Chakravarty, M. Lepage

Knockdown of the schizophrenia susceptibility gene TCF4 alters gene expression and proliferation of progenitor cells from the developing human neocortex
M.J. Hill, R. Killick, K. Navarrete, A. Maruszak, G.M. McLaughlin, B.P. Williams, N.J. Bray

Psychobiological response to pain in female adolescents with nonsuicidal self-injury
J. Koenig, L. Rinnewitz, M. Warth, T.K. Hillecke, R. Brunner, F. Resch, M. Kaess

Neural correlates of an attentional bias to health-threatening stimuli in individuals with pathological health anxiety
D. Mier, J. Bailer, J. Ofer, T. Kerstner, V. Zamoscik, F. Rist, M. Witthöft, C. Diener

CCNP News and Views

Canadian College of Neuropsychopharmacology 2017 award winners

Psychopharmacology for the Clinician

Pharmacotherapy of trichotillomania
V. Sharma

March 2017

J Psychiatry Neurosci 2017;42(2)


The gut microbiota and psychiatric illness
G. MacQueen, M. Surette, P. Moayyedi

Research Papers

Abstinence reverses EEG-indexed attention bias between drug-related and pleasant stimuli in cocaine-addicted individuals
M.A. Parvaz, S.J. Moeller, P. Malaker, R. Sinha, N. Alia-Klein, R.Z. Goldstein

Cognitive control deficit in patients with first-episode schizophrenia is associated with complex deviations of early brain development
O. Gay, M. Plaze, C. Oppenheim, R. Gaillard, J.-P. Olié, M.-O. Krebs, A. Cachia

COMT Val158Met polymorphism moderates the association between PTSD symptom severity and hippocampal volume
J.P. Hayes, M.W. Logue, A. Reagan, D. Salat, E.J. Wolf, N. Sadeh, J.M. Spielberg, E. Sperbeck, S.M. Hayes, R.E. McGlinchey, W.P. Milberg, M. Verfaellie, A. Stone, S.A. Schichman, M.W. Miller

Cortical morphology as a shared neurobiological substrate of attention-deficit/hyperactivity symptoms and executive functioning: a population-based pediatric neuroimaging study
S.E. Mous, T. White, R.L. Muetzel, H. El Marroun, J. Rijlaarsdam, T.J.C. Polderman, V.W. Jaddoe, F.C. Verhulst, D. Posthuma, H. Tiemeier

Effects of dopaminergic genes, prenatal adversities, and their interaction on attention-deficit/hyperactivity disorder and neural correlates of response inhibition
D. van der Meer, C.A. Hartman, D. van Rooij, B. Franke, D.J. Heslenfeld, J. Oosterlaan, S.V. Faraone, J.K. Buitelaar, P.J. Hoekstra

Familial and environmental influences on brain volumes in twins with schizophrenia
M.M. Picchioni, F. Rijsdijk, T. Toulopoulou, C. Chaddock, J.H. Cole, U. Ettinger, A. Oses, H. Metcalfe, R.M. Murray, P. McGuire

Δ9-Tetrahydrocannabinol decreases willingness to exert cognitive effort in male rats
M.M. Silveira, W.K. Adams, M. Morena, M.N. Hill, C.A. Winstanley


Correction: Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia

Psychopharmacology for the Clinician

Generic formulations of psychotropic medications and treatment response
V. Bhat, H.C. Margolese

January 2017

J Psychiatry Neurosci 2017;42(1)


The adaptive brain in mental health: overcoming inherited risk factors
P.R. Albert

Research Papers

Neurochemical correlates of rapid treatment response to electroconvulsive therapy in patients with major depression
S. Njau, S.H. Joshi, R. Espinoza, A.M. Leaver, M. Vasavada, A. Marquina, R.P. Woods, K.L. Narr

Altered brain connectivity in patients with schizophrenia is consistent across cognitive contexts
P. Orban, M. Desseilles, A. Mendrek, J. Bourque, P. Bellec, E. Stip

Shape analysis of the cingulum, uncinate and arcuate fasciculi in patients with bipolar disorder
Z.Y. Sun, J. Houenou, D. Duclap, S. Sarrazin, J. Linke, C. Daban, N. Hamdani, M.-A. d’Albis, P. Le Corvoisier, P. Guevara, M. Delavest, F. Bellivier, J. Almeida, A. Versace, C. Poupon, M. Leboyer, M. Phillips, M. Wessa, J.-F. Mangin

Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice
T.-N. Huang, Y.-P. Hsueh

Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice
M. Didriksen, K. Fejgin, S.R.O. Nilsson, M.R. Birknow, H.M. Grayton, P.H. Larsen, J.B. Lauridsen, V. Nielsen, P. Celada, N. Santana, P. Kallunki, K.V. Christensen, T.M. Werge, T.B. Stensbøl, J. Egebjerg, F. Gastambide, F. Artigas, J.F. Bastlund, J. Nielsen

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease
M.P. Serrano, R. Herrero-Labrador, H.S. Futch, J. Serrano, A. Romero, A.P. Fernandez, A. Samadi, M. Unzeta, J. Marco-Contelles, R. Martínez-Murillo


2016 Reviewers

Psychopharmacology for the Clinician

Refractory social anxiety disorder
M. Van Ameringen, B. Patterson

November 2016

J Psychiatry Neurosci 2016;41(6)


Legal responses to neuroscience
J. Fuss

Research Papers

Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis
A. Schmidt, L. Palaniyappan, R. Smieskova, A. Simon, A. Riecher-Rössler, U.E. Lang, P. Fusar-Poli, P. McGuire, S.J. Borgwardt

Partially restored resting-state functional connectivity in women recovered from anorexia nervosa
I. Boehm, D. Geisler, F. Tam, J.A. King, F. Ritschel, M. Seidel, F. Bernardoni, J. Murr, T. Goschke, V.D. Calhoun, V. Roessner, S. Ehrlich

Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals
S.M. Clark, A. Pocivavsek, J.D. Nicholson, F.M. Notarangelo, P. Langenberg, R.P. McMahon, J.E. Kleinman, T.M. Hyde, J. Stiller, T.T. Postolache, R. Schwarcz, L.H. Tonelli

Male-typical visuospatial functioning in gynephilic girls with gender dysphoria — organizational and activational effects of testosterone
S.M. Burke, B.P.C. Kreukels, P.T. Cohen-Kettenis, D.J. Veltman, D.T. Klink, J. Bakker

COMT and DAT1 genes are associated with hyperactivity and inattention traits in the 1993 Pelotas Birth Cohort: evidence of sex-specific combined effect
G.C. Akutagava-Martins, A. Salatino-Oliveira, C. Kieling, J.P. Genro, G.V. Polanczyk, L. Anselmi, A.M.B. Menezes, H. Gonçalves, F.C. Wehrmeister, F.C. Barros, S.M. Callegari-Jacques, L.A. Rohde, M.H. Hutz

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population
X. Yin, N.E. Wineinger, K. Wang, W. Yue, N. Norgren, L. Wang, W. Yao, X. Jiang, B. Wu, Y. Cui, C. Shen, H. Cheng, F. Zhou, G. Chen, X. Zuo, X. Zheng, X. Fan, H. Wang, L. Wang, J. Lee, M. Lam, E.S. Tai, Z. Zhang, Q. Huang, L. Sun, J. Xu, S. Yang, K.C. Wilhelmsen, J. Liu, N.J. Schork, X. Zhang

The effect of methylphenidate intake on brain structure in adults with ADHD in a placebo-controlled randomized trial
L. Tebartz van Elst, S. Maier, S. Klöppel, E. Graf, C. Killius, M. Rump, E. Sobanski, D. Ebert, M. Berger, A. Warnke, S. Matthies, E. Perlov, A. Philipsen

Psychopharmacology for the Clinician

Clozapine for the management of persistent catatonia
K. Tabbane, S. Halayem, R. Joober

Letters to the Editor

Concepts and misconceptions regarding clinical staging models
J. Shah, J. Scott

Concepts and misconceptions regarding clinical staging models – Author response
M. Alda, F. Kapczinski

September 2016

J Psychiatry Neurosci 2015;41(5)


Staging model raises fundamental questions about the nature of bipolar disorder
M. Alda, F. Kapczinski

Research Papers

Objective sleep disturbances are associated with greater waking resting-state connectivity between the retrosplenial cortex/ hippocampus and various nodes of the default mode network
W. Regen, S.D. Kyle, C. Nissen, B. Feige, C. Baglioni, J. Hennig, D. Riemann, K. Spiegelhalder

Prediction error and somatosensory insula activation in women recovered from anorexia nervosa
G.K.W. Frank, S. Collier, M.E. Shott, R.C. O’Reilly

Proactive response inhibition abnormalities in the sensorimotor cortex of patients with schizophrenia
A.R. Mayer, F.M. Hanlon, A.B. Dodd, R.A. Yeo, K.Y. Haaland, J.M. Ling, S.G. Ryman

Cocaine cue–induced dopamine release in the human prefrontal cortex
M.S. Milella, A. Fotros, P. Gravel, K.F. Casey, K. Larcher, J.A.J. Verhaeghe, S.M.L. Cox, A.J. Reader, A. Dagher, C. Benkelfat, M. Leyton

Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders
K.C. Skåtun, T. Kaufmann, S. Tønnesen, G. Biele, I. Melle, I. Agartz, D. Alnæs, O.A. Andreassen, L.T. Westlye

MicroRNA-326 acts as a molecular switch in the regulation of midbrain urocortin 1 expression
A. Aschrafi, J.M. Verheijen, P.M. Gordebeke, N. F. Olde Loohuis, K. Menting, A. Jager, M. Palkovits, B. Geenen, A. Kos, G.J.M. Martens, J.C. Glennon, B.B. Kaplan, B. Gaszner, T. Kozicz

Neural signature of behavioural inhibition in women with bulimia nervosa
M. Skunde, S. Walther, J.J. Simon, M. Wu, M. Bendszus, W. Herzog, H.-C. Friederich

Psychopharmacology for the Clinician

Managing the comorbidity of schizophrenia and ADHD
A. Gough, J. Morrison

July 2016


Deconstructing the mental health crisis: 5 uneasy pieces
Z. Merali, H. Anisman

Deconstructing the mental health crisis in only 2 pieces
R. Joober

Research Papers

Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers
C. Alquézar, A. de la Encarnación, F. Moreno, A. López de Munain,
Á. Martín-Requero

Cortical thickness, volume and surface area in patients with bipolar disorder types I and II
C. Abé, C.-J. Ekman, C. Sellgren, P. Petrovic, M. Ingvar, M. Landén

Male veterans with PTSD exhibit aberrant neural dynamics during working memory processing: an MEG study
T.J. McDermott, A.S. Badura-Brack, K.M. Becker, T.J. Ryan, M.M. Khanna,
E. Heinrichs-Graham, T.W. Wilson

Anomalous basal ganglia connectivity and obsessive–compulsive behaviour in patients with Prader Willi syndrome
J. Pujol, L. Blanco-Hinojo, S. Esteba-Castillo, A. Caixàs, B.J. Harrison,
M. Bueno, J. Deus, M. Rigla, D. Macià, J. Llorente-Onaindia, R. Novell-Alsina

Voxel-based morphometry analysis reveals frontal brain differences in participants with ADHD and their unaffected siblings
J. Bralten, C.U. Greven, B. Franke, M. Mennes, M.P. Zwiers, N.N.J. Rommelse, C. Hartman, D. van der Meer, L. O’Dwyer, J. Oosterlaan, P.J. Hoekstra, D. Heslenfeld, A. Arias-Vasquez, J.K. Buitelaar

An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive–compulsive disorder
I. van de Vondervoort, G. Poelmans, A. Aschrafi, D.L. Pauls, J.K. Buitelaar, J.C. Glennon, B. Franke

Unilateral and bilateral MRI-targeted repetitive transcranial magnetic stimulation for treatment-resistant depression: a randomized controlled study
D.M. Blumberger, J.J. Maller, L. Thomson, B.H. Mulsant, T.K. Rajji,
M. Maher, P.E. Brown, J. Downar, F. Vila-Rodriguez, P.B. Fitzgerald,
Z.J. Daskalakis

Psychopharmacology for the Clinician

Elevated clozapine plasma concentration secondary to a urinary tract infection: proposed mechanisms
L.H.N. Lee, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn

May 2016


Dynamic endophenotypes and longitudinal trajectories: capturing changing aspects of development in early psychosis
J.L. Shah, M.M. Chakravarty, R. Joober, M. Lepage

Research Papers

Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia
M. Kirschner, O.M. Hager, M. Bischof, M.N. Hartmann, A. Kluge, E. Seifritz, P.N. Tobler, S. Kaiser

Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study
T.T. van Sloten, G.F. Mitchell, S. Sigurdsson, M.A. van Buchem, P.V. Jonsson, M.E. Garcia, T.B. Harris, R.M.A. Henry, A.S. Levey, C.D.A. Stehouwer, V. Gudnason, L.J. Launer

Selective genetic disruption of dopaminergic, serotonergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behaviour
E. Isingrini, L. Perret, Q. Rainer, S. Sagueby, L. Moquin, A. Gratton, B. Giros

Facial emotion processing in patients with social anxiety disorder and Williams–Beuren syndrome: an fMRI study
C. Binelli, A. Muñiz, S. Subira, R. Navines, L. Blanco-Hinojo, D. Perez-Garcia, J. Crippa, M. Farré, L. Pérez-Jurado, J. Pujol, R. Martin-Santos

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males
D. Stacey, A. Lourdusamy, B. Ruggeri, M. Maroteaux, T. Jia, A. Cattrell, C. Nymberg, T. Banaschewski, S. Bhattacharyya, H. Band, G. Barker, A. Bokde, C. Buchel, F. Carvalho, P. Conrod, S. Desrivieres, A. Easton, M. Fauth-Buehler, A. Fernandez-Medarde, H. Flor, V. Frouin, J. Gallinat, H. Garavanh, A. Heinz, B. Ittermann, M. Lathrop, C. Lawrence, E. Loth, K. Mann, J.-L. Martinot, F. Nees, T. Paus, Z. Pausova, M. Rietschel, A. Rotter, E. Santos, M. Smolka, W. Sommer, M. Mameli, R. Spanagel, J.-A. Girault, C. Mueller, G. Schumann; on behalf of the IMAGEN consortium

The hippocampi of children with chromosome 22q11.2 deletion syndrome have localized anterior alterations that predict severity of anxiety
J.A. Scott, N. Goodrich-Hunsaker, K. Kalish, A. Lee, M.R. Hunsaker, C.M. Schumann, O.T. Carmichael, T.J. Simon

To drink or not to drink: Harmful drinking is associated with hyperactivation of reward areas rather than hypoactivation of control areas in men
H. Stuke, S. Gutwinski, C.E. Wiers, T.T. Schmidt, S. Gröpper, J. Parnack, C. Gawron, C.H. Attar, S. Spengler, H. Walter, A. Heinz, F. Bermpohl

Elevated prefrontal cortex GABA in patients with major depressive disorder after TMS treatment measured with proton magnetic resonance spectroscopy
M.J. Dubin, X. Mao, S. Banerjee, Z. Goodman, K.A.B. Lapidus, G. Kang, C. Liston, D.C. Shungu

Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia
B. García-Bueno, P. Gassó, K.S. MacDowell, L.F. Callado, S. Mas, M. Bernardo, A. Lafuente, J.J. Meana, J.C. Leza

CCNP News and Views

Canadian College of Neuropsychopharmacology 2015 award winners

Psychopharmacology for the Clinician

Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
R.M. Procyshyn, J.L. Banasch, A.M. Barr, W.G. Honer

March 2016

J Psychiatry Neurosci 2016;41(2)


Legalizing marijuana
M. Leyton

Research Papers

Reduced error signalling in medication-naive children with ADHD: associations with behavioural variability and post-error adaptations
K.J. Plessen, E.A. Allen, H. Eichele, H. van Wageningen, M. Farstad Høvik, L. Sørensen, M. Kalsås Worren, K. Hugdahl, T. Eichele

Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis
G.A. Alvares, D.S. Quintana, I.B. Hickie, A.J. Guastella

Grey matter volume increase following electroconvulsive therapy in patients with late life depression: a longitudinal MRI study
F. Bouckaert, F.-L. De Winter, L. Emsell, A. Dols, D. Rhebergen, M. Wampers, S. Sunaert, M. Stek, P. Sienaert, M. Vandenbulcke

Structural covariance of neostriatal and limbic regions in patients with obsessive–compulsive disorder
M. Subirà, M. Cano, S.J. de Wit, P. Alonso, N. Cardoner, M.Q. Hoexter, J.S. Kwon, T. Nakamae, C. Lochner, J.R. Sato, W.H. Jung, J. Narumoto, D.J. Stein, J. Pujol, D. Mataix-Cols, D.J. Veltman, OCD Brain Imaging Consortium, J.M. Menchón, O.A. van den Heuvel, C. Soriano-Mas

Identification of segregated regions in the functional brain connectome of autistic patients by a combination of fuzzy spectral clustering and entropy analysis
J.R. Sato, J. Balardin, M.C. Vidal, A. Fujita

Frontal fasciculi and psychotic symptoms in antipsychotic-naive patients with schizophrenia before and after 6 weeks of selective dopamine D2/3 receptor blockade
B.H. Ebdrup, J.M. Raghava, M.Ø. Nielsen, E. Rostrup, B. Glenthøj

Aberrant network connectivity during error processing in patients with schizophrenia
R. Voegler, M.P.I. Becker, A. Nitsch, W.H.R. Miltner, T. Straube 

Eye-tracking reveals a slowdown of social context processing during intention attribution in patients with schizophrenia
P. Roux, E. Brunet-Gouet, C. Passerieux, F. Ramus

Psychopharmacology for the Clinician

Treating comorbid premenstrual dysphoric disorder in women with bipolar disorder
M. Smith, B.N. Frey

Letters to the Editor

Smoking as a confounder of the association of suicidality with serum lipid levels
I. Berlin, A. Luquiens, H. Aubin

Smoking as a confounder of the association of suicidality with serum lipid levels – Author response
S. Wu, J. Hou, P. Mao

January 2016

J Psychiatry Neurosci 2016;41(1)


Neurolaw: recognizing opportunities and challenges for psychiatry
G. Meynen

Research Papers

Abnormal functional global and local brain connectivity in female patients with anorexia nervosa
D. Geisler, V. Borchardt, A.R. Lord, I. Boehm, F. Ritschel, J. Zwipp, S. Clas, J.A. King, S. Wolff-Stephan, V. Roessner, M. Walter, S. Ehrlich

Time course of facial emotion processing in women with borderline personality disorder: an ERP study
N.A. Izurieta Hidalgo, R. Oelkers-Ax, K. Nagy, F. Mancke, M. Bohus, S.C. Herpertz, K. Bertsch

Potential serum biomarkers from a metabolomics study of autism
H. Wang, S. Liang, M. Wang, J. Gao, C. Sun, J. Wang, W. Xia, S. Wu, S.J. Sumner, F. Zhang, C. Sun, L. Wu

Healthy co-twins of patients with affective disorders show reduced risk-related activation of the insula during a monetary gambling task
J. Macoveanu, K. Miskowiak, L.V. Kessing, M. Vinberg, H.R. Siebner

Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers
K.J. Hartwell, C.A. Hanlon, X. Li, J.J. Borckardt, M. Canterberry, J.J. Prisciandaro, M.M. Moran-Santa Maria, T. LeMatty, M.S. George, K.T. Brady

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies
S. Wu, Y. Ding, F. Wu, G. Xie, J. Hou, P. Mao


2015 Reviewers

Psychopharmacology for the Clinician

Successful management of clozapine adverse effects with extended (alternate day) antipsychotic dosing in a patient with schizophrenia
V. Kumar, L. Sharma, S. Madival, G. Venkatasubramanian