January 2012

J Psychiatry Neurosci 2012;37(1)


Psychiatry’s age of enlightenment: optogenetics and the discovery of novel targets for the treatment of psychiatric disorders
M.M. Sidor

Review Papers

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health
J.-M. Beaulieu

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction
L. Palaniyappan, P.F. Liddle

Research Papers

Abnormal hippocampal activation in patients with extensive history of major depression: an fMRI study
A.M.B. Milne, G.M. MacQueen, G.B.C. Hall

Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression
T. Frodl, A. Carballedo, A.J. Fagan, D. Lisiecka, Y. Ferguson, J.F. Meaney

Parent-of-origin effects of FAS and PDLIM1 in attention-deficit/hyperactivity disorder
K.-S. Wang, X. Liu, Q. Zhang, N. Aragam, Y. Pan

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
M. Holtze, P. Saetre, G. Engberg, L. Schwieler, T. Werge, O.A. Andreassen, H. Hall, L. Terenius, I. Agartz, E.G. Jönsson, M. Schalling, S. Erhardt


2011 Reviewers

Psychopharmacology for the Clinician

Adverse events associated with switching antipsychotics
J. Su, A.M. Barr, R.M. Procyshyn

March 2012

J Psychiatry Neurosci 2012;37(2)


Abnormal synaptic pruning in schizophrenia: Urban myth or reality?
P. Boksa

Research Papers

Stress response in postpartum women with and without obsessive–compulsive symptoms: an fMRI study
C. Lord, M. Steiner, C.N. Soares, C.L. Carew, G.B. Hall

Working memory processing of traumatic material in women with posttraumatic stress disorder
L. Landré, C. Destrieux, F. Andersson, L. Barantin, Y. Quidé, G. Tapia, N. Jaafari, D. Clarys, P. Gaillard, M. Isingrini, W. El-Hage

Event-related potentials and changes of brain rhythm oscillations during working memory activation in patients with first-episode psychosis
P. Missonnier, F.R. Herrmann, A. Zanello, M. Badan Bâ, L. Curtis, D.Canovas, F. Chantraine, J. Richiardi, P. Giannakopoulos, M.C.G. Merlo

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis
P. Fusar-Poli

Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain
O. Chernoloz, M. El Mansari, P. Blier

Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?
P. Suchankova, J. Klang, C. Cavanna, G. Holm, S. Nilsson, E.G. Jönsson, A. Ekman

Differential association between the norepinephrine transporter gene and ADHD: role of sex and subtype
S.M. Sengupta, N. Grizenko, G.A. Thakur, J. Bellingham, R. DeGuzman, S. Robinson, M. TerStepanian, A. Poloskia, S.M. Shaheen, M.-E. Fortier, Z. Choudhry, R. Joober

Psychopharmacology for the Clinician

Managing pathologic aggression in people with psychotic disorders
D. Bourget, A. Labelle

May 2012

J Psychiatry Neurosci 2012;37(3)


Publication bias: What are the challenges and can they be overcome?
R. Joober, N. Schmitz, L. Annable, P. Boksa

Review Paper

Systematic review of the neural basis of social cognition in patients with mood disorders
A.M. Cusi, A. Nazarov, K. Holshausen, G.M. MacQueen, M.C. McKinnon 

Research Papers

Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies
P. Fusar-Poli, O. Howes, A. Bechdolf, S. Borgwardt

Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study
T. Hajek, M. Bauer, A. Pfennig, J. Cullis, J. Ploch, C. O’Donovan, G. Bohner, R. Klingebiel, L.T. Young, G.M. MacQueen, M. Alda

Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive–compulsive disorder
C. Lochner, J.-P. Fouché, S. du Plessis, B. Spottiswoode, S. Seedat, N. Fineberg, S.R. Chamberlain, D.J. Stein

Psychopharmacology for the Clinician

Will lithium damage my kidneys?
T.J. Raedler

May 2011

J Psychiatry Neurosci 2011;36(3)


The 1000 Genomes Project: deep genomic sequencing waiting for deep psychiatric phenotyping
R. Joober

Review Paper

Atypical scanpaths in schizophrenia: Evidence of a trait- or state-dependent phenomenon?
S.A. Beedie, D.M. St. Clair, P.J. Benson

Research Papers

Effect of executive functioning, decision-making and self-reported impulsivity on the treatment outcome of pathologic gambling
E.M. Álvarez-Moya, C. Ochoa, S. Jiménez-Murcia, M.N. Aymamí, M. Gómez-Peña, F. Fernández-Aranda, J. Santamaría, L. Moragas, F. Bove, J.M. Menchón

Structural alterations in lateral prefrontal, parietal and posterior midline regions of men with chronic posttraumatic stress disorder
C. Eckart, C. Stoppel, J. Kaufmann, C. Tempelmann, H. Hinrichs, T. Elbert, H.-J. Heinze, I.-T. Kolassa

Depression in patients with Huntington disease correlates with alterations of the brain stem raphe depicted by transcranial sonography
C. Krogias, K. Strassburger, J. Eyding, R. Gold, C. Norra, G. Juckel, C. Saft, D. Ninphius

Decreased BDNF, trkB-TK+ and GAD67 mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders
M. Thompson Ray, C.S. Weickert, E. Wyatt, M.J. Webster

CCNP News and Views

2011 award winners

Psychopharmacology for the Clinician

Treatment of ADHD in patients unresponsive to methylphenidate
L. Hechtman

July 2011

J Psychiatry Neurosci 2011;36(4)


My 21 years with the Journal of Psychiatry and Neuroscience, with observations on editors, editorial boards, authors and reviewers
S.N. Young

Review Paper

Contribution of nonprimate animal models in understanding the etiology of schizophrenia
N.L. Lazar, R.W.J. Neufeld, D.P. Cain

Research Papers

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study
P. Fusar-Poli, N. Crossley, J. Woolley, F. Carletti, R. Perez-Iglesias, M. Broome, L. Johns, P. Tabraham, E. Bramon, P. McGuire

Topiramate diminishes fear memory consolidation and extinguishes conditioned fear in rats
P.A. Schmidt do Prado-Lima, M.F. Perrenoud, C.H. Kristensen, M. Cammarota, I. Izquierdo

Structural brain abnormalities common to posttraumatic stressdisorder and depression
M.C.W. Kroes, M.D. Rugg, M.G. Whalley, C.R. Brewin

Psychopharmacology for the Clinician

Managing anxiety and depressive symptoms in adults with autism-spectrum disorders
K. Boyd, M. Woodbury-Smith, P. Szatmari

September 2011

J Psychiatry Neurosci 2011;36(5)


Inflaming depression
H. Anisman

Review Paper

Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system
C. Flores

Research Papers

Differential brain glucose metabolic patterns in antipsychotic-naive first-episode schizophrenia with and without auditory verbal hallucinations
G. Horga, E. Parellada, F. Lomeña, E. Fernández-Egea, A. Mané, M. Font, C. Falcón, A.B. Konova, J. Pavia, D. Ros, M. Bernardo

Fluoxetine affects GluK2 editing, glutamate-evoked Ca2+ influx and extracellular signal-regulated kinase phosphorylation in mouse astrocytes
B. Li, S. Zhang, H. Zhang, L. Hertz, L. Peng

Psychopharmacology for the Clinician

Bright light for nonseasonal depression?
S.N. Young

November 2011

J Psychiatry Neurosci 2011;36(6)


What is a functional genetic polymorphism? Defining classes of functionality
P.R. Albert

Research Papers

Dysconnectivity of multiple resting-state networks in patients with schizophrenia who have persistent auditory verbal hallucinations
N.D. Wolf, F. Sambataro, N. Vasic, K. Frasch, M. Schmid, C. Schönfeldt-Lecuona, P.A. Thomann, R.C. Wolf

Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John’s wort: an [11C]-harmine PET study
J. Sacher, S. Houle, J. Parkes, P. Rusjan, S. Sagrati, A.A. Wilson, J.H. Meyer

Emotion recognition and experience in Huntington disease: a voxel-based morphometry study
R. Ille, A. Schäfer, W. Scharmüller, C. Enzinger, H. Schöggl, H.-P. Kapfhammer, A. Schienle

Combined analysis of grey matter voxel-based morphometry and white matter tract-based spatial statistics in late-life bipolar disorder
S. Haller, A. Xekardaki, C. Delaloye, A. Canuto, K.O. Lövblad, G. Gold, P. Giannakopoulos

Aberrant connectivity of resting-state networks in borderline personality disorder
R.C. Wolf, F. Sambataro, N. Vasic, M. Schmid, P.A. Thomann, S.D. Bienentreu, N.D. Wolf

Can Asperger syndrome be distinguished from autism? An anatomic likelihood meta-analysis of MRI studies
K.K. Yu, C. Cheung, S.E. Chua, G.M. McAlonan

Psychopharmacology for the Clinician

Discontinuation of lithium because of side effects
T. Hajek, M. Alda, P. Grof

July 2012

J Psychiatry Neurosci 2012;37(4)


Illness comorbidity as a biomarker?
H. Anisman, S. Hayley

Research Papers

Behavioural therapy based on distraction alleviates impaired fear extinction in male serotonin transporter knockout rats
L.J.P. Nonkes, M. de Pooter, J.R. Homberg

Brain functional connectivity during induced sadness in patients with obsessive–compulsive disorder
L.F. Fontenelle, B.J. Harrison, J. Pujol, C.G. Davey, A. Fornito, E. Bora, C. Pantelis, M. Yücel

Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder
R.K. Sripada, A.P. King, S.N. Garfinkel, X. Wang, C.S. Sripada, R.C. Welsh, I. Liberzon

Decreased cognitive control in response to negative information in patients with remitted depression: an event-related potential study
M.-A. Vanderhasselt, R. De Raedt, D.G. Dillon, S.J. Dutra, N. Brooks, D.A. Pizzagalli

Nonlinear analysis of electroencephalogram at rest and during cognitive tasks in patients with schizophrenia
E. Carlino, M. Sigaudo, A. Pollo, F. Benedetti, T. Mongini, F. Castagna, S. Vighetti, P. Rocca

Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder
R. Lyddon, S. Navarrett, S. Dracheva

Association between the NMDA glutamate receptor GRIN2B gene and obsessive–compulsive disorder
P. Alonso, M. Gratacós, C. Segalàs, G. Escaramís, E. Real, M. Bayés, J. Labad, C. López-Solà, X. Estivill, J.M. Menchón

Psychopharmacology for the Clinician

Prophylaxis and treatment of bipolar disorder in older adults
C.L. Allan, K.P. Ebmeier

September 2012

J Psychiatry Neurosci 2012;37(5)


Drugs for kids: Good or bad?
P.R. Albert

Research Papers

Schizophrenia with preserved insight is associated with increased perfusion of the precuneus
C. Faget-Agius, L. Boyer, R. Padovani, R. Richieri, O. Mundler, C. Lançon, E. Guedj

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter
A. Ruef, L. Curtis, G. Moy, S. Bessero, M. Badan Bâ, F. Lazeyras, K.-O. Lövblad, S. Haller, A. Malafosse, P. Giannakopoulos, M. Merlo

Neurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster
M. Kaur, R.A. Battisti, J. Lagopoulos, P.B. Ward, I.B. Hickie, D.F. Hermens

Food motivation circuitry hypoactivation related to hedonic and nonhedonic aspects of hunger and satiety in women with active anorexia nervosa and weight-restored women with anorexia nervosa
L.M. Holsen, E.A. Lawson, J. Blum, E. Ko, N. Makris, P.K. Fazeli, A. Klibanski, J.M. Goldstein

Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis
T. Hajek, M. Kopecek, C. Höschl, M. Alda

Psychopharmacology for the Clinician

Antidepressant medication to treat anxiety in patients with bipolar disorder
S. Hassel, G. MacQueen

November 2012

J Psychiatry Neurosci 2012;37(6)


Loose ends of psychiatric research
M. Alda, T. Hajek

Review Paper

Inhibition of the cortex using transcranial magnetic stimulation in psychiatric populations: current and future directions
N. Radhu, L.N. Ravindran, A.J. Levinson, Z.J. Daskalakis

Research Papers

Reduced neural activity of the prefrontal cognitive control circuitry during response inhibition to negative words in people with schizophrenia
A. Vercammen, R. Morris, M.J. Green, R. Lenroot, J. Kulkarni, V.J. Carr, C.S. Weickert, T.W. Weickert

Comparison of brain volume abnormalities between ADHD and conduct disorder in adolescence
M.C. Stevens, E. Haney-Caron

Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study
L. Palaniyappan, P.F. Liddle

Differential effects of 3 classes of antidiabetic drugs on olanzapine-induced glucose dysregulation and insulin resistance in female rats
H.N. Boyda, R.M. Procyshyn, L. Tse, E. Hawkes, C.H. Jin, C.C.Y. Pang, W.G. Honer, A.M. Barr

Psychopharmacology for the Clinician

Management of comorbid Tourette syndrome and attention-deficit/ hyperactivity disorder: Are psychostimulants an option?
T. Pringsheim

January 2013

J Psychiatry Neurosci 2013;38(1)


What does it mean to have enough evidence?
G. MacQueen

Review Paper

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology
T.J. Revett, G.B. Baker, J. Jhamandas, S. Kar

Research Papers

Dexamphetamine selectively increases 40 Hz auditory steady state response power to target and nontarget stimuli in healthy humans
M.A. Albrecht, G. Price, J. Lee, R. Iyyalol, M.T. Martin-Iverson

Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia
T.B. Hammer, B. Oranje, A. Skimminge, B. Aggernaes, B.H. Ebdrup, B. Glenthøj, W. Baaré

Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder
K. Xu, W. Jiang, L. Ren, X. Ouyang, Y. Jiang, F. Wu, L. Kong, F. Womer, Z. Liu, H.P. Blumberg, Y. Tang, F. Wang

Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD
Y. Liao, X. Huang, Q. Wu, C. Yang, W. Kuang, M. Du, S. Lui, Q. Yue, R.C.K. Chan, G.J. Kemp, Q. Gong

Functional network connectivity of pain-related resting state networks in somatoform pain disorder: an exploratory fMRI study
A. Otti, H. Guendel, P. Henningsen, C. Zimmer, A.M. Wohlschlaeger, M. Noll-Hussong

Psychopharmacology for the Clinician

SSRIs in a case of selective mutism
K. Manassis, D. Avery


Thank you to those who reviewed submissions to the journal in 2012

March 2013

J Psychiatry Neurosci 2013;38(2)


A way forward for research on biomarkers for psychiatric disorders
P. Boksa


Single treatments that have lasting effects: some thoughts on the antidepressant effects of ketamine and botulinum toxin and the anxiolytic effect of psilocybin
S.N. Young

Review Paper

Overview of potential procedural and participant- related confounds for neuroimaging of the resting state
N.W. Duncan, G. Northoff

Research Papers

Dopamine D2 and D3 binding in people at clinical high risk for schizophrenia, antipsychotic-naive patients and healthy controls while performing a cognitive task
I. Suridjan, P. Rusjan, J. Addington, A.A. Wilson, S. Houle, R. Mizrahi

Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden
J. de Diego-Adeliño, M.J. Portella, B. Gómez-Ansón, O. López-Moruelo, M. Serra-Blasco, Y. Vives, D. Puigdemont, R. Pérez-Egea, E. Álvarez, V. Pérez

Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression
D.M. Lisiecka, A. Carballedo, A.J. Fagan, Y. Ferguson, J. Meaney, T. Frodl

Morphometric differences in central stress-regulating structures between women with and without borderline personality disorder
A. Kuhlmann, K. Bertsch, I. Schmidinger, P.A. Thomann, S.C. Herpertz

Psychopharmacology for the Clinician

Antidepressants and QTc prolongation
R.W. Lam

March 2014

J Psychiatry Neurosci 2014;39(2)


Clearing the smoke: What do we know about adolescent cannabis use and schizophrenia?
M.N. Hill

Research Papers

Characterization of major depressive disorder using a multiparametric classification approach based on high resolution structural images
L. Qiu, X. Huang, J. Zhang, Y. Wang, W. Kuang, J. Li, X. Wang, L. Wang, X. Yang, S. Lui, A. Mechelli, Q. Gong

Abnormal synchrony of resting state networks in premanifest and symptomatic Huntington disease: the IMAGE-HD study
G.R. Poudel, G.F. Egan, A. Churchyard, P. Chua, J.C. Stout, N. Georgiou-Karistianis

Neural correlates of recognition memory of social information in people with schizophrenia
P.-O. Harvey, M. Lepage

Effects of dopaminergic modulation on automatic semantic priming: a double-blind study
C. Andreou, K. Veith, V.P. Bozikas, T.M. Lincoln, S. Moritz

Impaired musical ability in people with schizophrenia
S. Hatada, K. Sawada, M. Akamatsu, E. Doi, M. Minese, M. Yamashita, A.E. Thornton, W.G. Honer, S. Inoue

Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder
E. Bøen, L.T. Westlye, T. Elvsåshagen, B. Hummelen, P.K. Hol, B. Boye, S. Andersson, S. Karterud, U.F. Malt

Cognitive impairment with and without depression history: an analysis of white matter microstructure
S.L. Duffy, M. Paradise, I.B. Hickie, S.J.G. Lewis, S.L. Naismith, J. Lagopoulos

Psychopharmacology for the Clinician

Assessment of adult attention-deficit/ hyperactivity disorder
V. Bhat, J. Paris

May 2013

J Psychiatry Neurosci 2013;38(3)


On the simple and the complex in psychiatry, with reference to DSM 5 and Research Domain Criteria
R. Joober

Review Paper

Cytochrome P450–mediated drug metabolism in the brain
S. Miksys, R.F. Tyndale

Research Papers

Emotional modulation of motor response inhibition in women with borderline personality disorder: an fMRI study
G.A. Jacob, K. Zvonik, S. Kamphausen, A. Sebastian, S. Maier, A. Philipsen, L. Tebartz van Elst, K. Lieb, O. Tüscher

Functional neural correlates of emotional expression processing deficits in behavioural variant frontotemporal dementia
K. Virani, S. Jesso, A. Kertesz, D. Mitchell, E. Finger

Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice
Y. Lee, H. Son, G. Kim, S. Kim, D.H. Lee, G.S. Roh, S.S. Kang, G.J. Cho, W.S. Choi, H.J. Kim

Protocadherin α (PCDHA) as a novel susceptibility gene for autism
A. Anitha, I. Thanseem, K. Nakamura, K. Yamada, Y. Iwayama, T. Toyota, Y. Iwata, K. Suzuki, T. Sugiyama, M. Tsujii, T. Yoshikawa, N. Mori

CCNP News and Views

In memoriam: Claude de Montigny, 1945–2012

Canadian College of Neuropsychopharmacology 2013 award winners

Psychopharmacology for the Clinician

Diagnosis and management of periodic catatonia
W.M. Hervey, J.T. Stewart, G. Catalano

January 2014

J Psychiatry Neurosci 2014;39(1)


Light up your life: Optogenetics for depression?
P.R. Albert

Review Paper

Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology
S. Comai, G. Gobbi

Research Papers

Abnormal interhemispheric connectivity in male psychopathic offenders
S.S. Hoppenbrouwers, D.R. De Jesus, Y. Sun, T. Stirpe, D. Hofman, J. McMaster, G. Hughes, Z.J. Daskalakis, D.J.L.G. Schutter

Association of a risk allele of ANK3 with cognitive performance and cortical thickness in patients with first-episode psychosis
C. Cassidy, L. Buchy, M. Bodnar, J. Dell’Elce, Z. Choudhry, F. Fathalli, S. Sengupta, R. Fox, A. Malla, M. Lepage, S. Iyer, R. Joober

Levomilnacipran ER 40 mg and 80 mg in patients with major depressive disorder: a phase III, randomized, double-blind, fixed-dose, placebo-controlled study
D. Bakish, A. Bose, C. Gommoll, C. Chen, R. Nunez, W.M. Greenberg, M. Liebowitz, A. Khan

Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants
A. Chaney, A. Carballedo, F. Amico, A. Fagan, N. Skokauskas, J. Meaney, T. Frodl

Cerebellar motor learning deficits in medicated and medication-free men with recent-onset schizophrenia
M. Coesmans, C.H. Röder, A.E. Smit, S.K.E. Koekkoek, C.I. De Zeeuw, M.A. Frens, J.N. van der Geest


Possible role of more positive social behaviour in the clinical effect of antidepressant drugs
S.N. Young, D.S. Moskowitz, M. aan het Rot


2013 Reviewers

Psychopharmacology for the Clinician

Off-label antipsychotic use and tardive dyskinesia in at-risk populations: new drugs with old side effects
G. Remington, M. Hahn