RT Journal Article
SR Electronic
T1 Impaired interhemispheric connectivity in medication-naive patients with major depressive disorder
JF Journal of Psychiatry and Neuroscience
JO J Psychiatry Neurosci
FD Canadian Medical Association
SP 43
OP 48
DO 10.1503/jpn.110132
VO 38
IS 1
A1 Ke Xu
A1 Wenyan Jiang
A1 Ling Ren
A1 Xuan Ouyang
A1 Yifeng Jiang
A1 Feng Wu
A1 Lingtao Kong
A1 Fay Womer
A1 Zhening Liu
A1 Hilary P. Blumberg
A1 Yanqing Tang
A1 Fei Wang
YR 2013
UL http://jpn.ca/content/38/1/43.abstract
AB Background: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in major depressive disorder (MDD). The purpose of this study was to investigate interhemispheric connectivity in medication-naive patients with MDD by measuring fractional anisotropy in the CC with diffusion tensor imaging (DTI) techniques.Methods: We obtained DTI scans from medication-naive patients with MDD and from matched healthy controls. Fractional anisotropy values were compared using semiautomatic region of interest methods to localize the regional CC differences between these 2 groups.Results: We enrolled 27 patients and 27 controls in our study. Fractional anisotropy values were significantly lower in the anterior genu of the CC in the MDD group than in the control group (p = 0.009, corrected); results were not significantly different in any other CC subregions.Limitations: As patients with MDD were already experiencing acute episodes, future studies of individuals at risk for MDD are warranted to elucidate the interhemispheric connectivity abnormalities associated with the predisposition to MDD.Conclusion: The findings demonstrate abnormalities in the structural integrity of the anterior genu of the CC in medication-naive individuals with MDD, which may contribute to impairment of interhemispheric connectivity in patients with this disorder.