Table 2

Anatomic location, MNI coordinates (mm), and corrected p values corresponding to altered connectivity in resting state networks in pre-HD and symp-HD groups

	MNI coordinates, mm

Brain region	x	y	z	p value
Pre-HD < controls
Sensorimotor network
Right primary motor cortex (M1)	2	−32	62	0.042
Dorsal attention network
Right occipital fusiform gyrus	36	−78	−18	0.041
Symp-HD < controls
Dorsal attention network
Right
Middle frontal gyrus	32	0	60	0.010
Postcentral gyrus	32	−32	62	0.010
Precentral gyrus	44	−6	56	0.042
Left
Supramarginal gyrus	−36	−30	34	0.033
Paracingulate gyrus	−12	14	38	0.042
Angular gyrus	−38	−42	30	0.045
Superior frontal gyrus	−16	−10	60	0.041
Executive control network
Right putamen	34	−2	4	0.010
Symp-HD < pre-HD
Executive control network
Right superior parietal lobule	38	−44	54	0.021
Right putamen	34	−2	4	0.022
Symp-HD > pre-HD
Left frontoparietal network
Right hippocampus	34	−26	−8	0.036
Left middle frontal gyrus	−28	34	32	0.043

MNI = Montreal Neurological Institute; pre-HD = premanifest gene carriers of Huntington disease; symp-HD = symptomatic Huntington disease.