Summary of studies included in the meta-analysis of diffusion tensor imaging studies of patients with MDD
| Controls | Patients | |||||
|---|---|---|---|---|---|---|
| Study | No. (female) | Age, mean (SD) yr | No. (female) | Age, mean (SD) yr | Diagnosis | Medication |
| Versace et al. (20) | 24 (15) | 28 (9) | 16 (12) | 33 (10) | Recurrent MDD | Antidepressants |
| Blood et al. (25) | 22 (12) | 35 (12) | 22 (12) | 36 (12) | MDD | Antidepressants |
| Liu et al. (26) | 16 (12) | 30 | 16 (12) | 30 | MDD* | Antidepressants† |
| Ma et al. (14) | 14 (12) | 27 (7) | 14 (12) | 29 (8) | First-episode MDD | Medication naive |
| Abe et al. (27) | 42 (20) | 48 (13) | 21 (10) | 48 (14) | MDD | Not stated |
| Steele et al. (28) | 14 (7) | 43 | 15 (11) | 46 | Recurrent MDD | Multiple medications‡ |
| Wu et al. (29) | 21 (12) | 30 (8) | 23 (13) | 31 (9) | SSDE of MDD | Medication-naive |
| Zou et al. (30) | 45 (30) | 31 (10) | 45 (30) | 32 (9) | Non–late onset MDD | Antidepressants |
| Ouyang et al. (31) | 18 (9) | 27.0 (6.8) | 18 (9) | 27.4 (6.4) | MDD | Medication-naive |
| Zhu et al. (21) | 25 (14) | 20.3 (1.7) | 25 (14) | 20.6 (1.9) | MDD* | Medication-naive |
| Kieseppä et al. (22) | 20 (10) | 48.4 (0.3) | 16 (14) | 42.0 (11.6) | MDD | Medication-naive |
MDD = major depressive disorder; SD = standard devistion; SSDE = single shirt-duration episode.
↵* The sample included only young patients (aged 21 to 35 years) with MDD.
↵† 2 patients took antidepressants.
↵‡ Includes anticonvulsant mood stabilizers, antidepressants, antipsychotics, benzodiazepines and lithium treatment.