OBJECTIVE: Since all antipsychotics block dopamine D 2 receptors, the authors investigated
how well D 2 receptor occupancy in vivo predicts clinical response, extrapyramidal side …

Opinion Statement Interest in the negative symptoms of schizophrenia has increased rapidly
over the last several decades, paralleling a growing interest in functional, in addition to …

Impact of dose reduction of atypical antipsychotics on cognitive function has not been
investigated in stable patients with schizophrenia. In this open-label, 28-week, randomized …

Even though individuals with psychiatric conditions have a prevalence of smoking approximately
2–4 times greater than the general population, surprisingly little evidence exists to …

Objective: The therapeutic success of clozapine and risperidone has focused attention on
the interaction between the serotonin and dopamine systems as an avenue for superior …

In a double-blind study, 135 inpatients with a diagnosis of chronic schizophrenia were randomly
assigned to 8 weeks of treatment with one of six parallel treatments: risperidone (a new …

OBJECTIVE: Dopamine D 2 receptor occupancy measurements provide a valid predictor of
antipsychotic response, extrapyramidal side effects, and elevation of prolactin levels. The …

Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors evaluated …

The identification of schizophrenia's negative symptoms dates back to the earliest
descriptions of Kraepelin and Bleuler, who each highlighted the central role of avolition in the …

Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults
across different stages, phases, and symptom domains. Method: Guidelines were developed …