User profiles for Lena Palaniyappan

Lena K. Palaniyappan

Professor of Psychiatry, McGill University
Verified email at mcgill.ca
Cited by 9335

Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction

L Palaniyappan, PF Liddle - Journal of Psychiatry and Neuroscience, 2012 - jpn.ca
The insular cortex is one of the brain regions that show consistent abnormalities in both
structural and functional neuroimaging studies of schizophrenia. In healthy individuals, the …

Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia

…, ET Rolls, W Yang, L Palaniyappan… - Schizophrenia …, 2017 - academic.oup.com
Published reports of functional abnormalities in schizophrenia remain divergent due to lack
of staging point-of-view and whole-brain analysis. To identify key functional-connectivity …

[PDF][PDF] Neural primacy of the salience processing system in schizophrenia

L Palaniyappan, M Simmonite, TP White, EB Liddle… - Neuron, 2013 - cell.com
For effective information processing, two large-scale distributed neural networks appear to
be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (…

Localized connectivity in depression: a meta-analysis of resting state functional imaging studies

…, C Li, DP Auer, J Radua, L Palaniyappan - Neuroscience & …, 2015 - Elsevier
Resting-state fMRI studies investigating the pathophysiology of depression have identified
prominent abnormalities in large-scale brain networks. However, it is unclear if localized …

Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis

L Palaniyappan, V Balain, J Radua, PF Liddle - Schizophrenia research, 2012 - Elsevier
BACKGROUND: Despite being one of the most common symptoms of schizophrenia,
determining the neural correlates of auditory hallucinations still remains elusive with various …

Resolving heterogeneity in schizophrenia through a novel systems approach to brain structure: individualized structural covariance network analysis

Z Liu, L Palaniyappan, X Wu, K Zhang, J Du… - Molecular …, 2021 - nature.com
Reliable mapping of system-level individual differences is a critical first step toward precision
medicine for complex disorders such as schizophrenia. Disrupted structural covariance …

[HTML][HTML] Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry

W Cheng, L Palaniyappan, M Li, KM Kendrick… - npj …, 2015 - nature.com
Background: Wernicke’s concept of ‘sejunction’or aberrant associations among specialized
brain regions is one of the earliest hypotheses attempting to explain the myriad of symptoms …

Brain surface anatomy in adults with autism: the relationship between surface area, cortical thickness, and autistic symptoms

…, MC Lai, J Suckling, L Palaniyappan… - JAMA …, 2013 - jamanetwork.com
Context Neuroimaging studies of brain anatomy in autism spectrum disorder (ASD) have
mostly been based on measures of cortical volume (CV). However, CV is a product of 2 distinct …

Repetitive transcranial magnetic stimulation versus electroconvulsive therapy for major depression: a systematic review and meta-analysis

J Ren, H Li, L Palaniyappan, H Liu, J Wang, C Li… - Progress in Neuro …, 2014 - Elsevier
Electroconvulsive therapy (ECT) is the most effective treatment of depression. During the last
decades repetitive transcranial magnetic stimulation (rTMS), an alternative method using …

Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: a mega …

…, I Nenadic, D Öngür, M Ota, L Palaniyappan… - JAMA …, 2021 - jamanetwork.com
Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …