Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the
known genetic risk has been traced to rare variants, principally copy number variants (CNVs). …

The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments
in reciprocal social interaction and communication, and the presence of restricted and …

Many studies have supported a genetic etiology for autism. Here we report mutations in two
X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum …

SHANK3 (also known as ProSAP2) regulates the structural organization of dendritic spines
and is a binding partner of neuroligins; genes encoding neuroligins are mutated in autism …

Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic …

BACKGROUND: Patients with bipolar disorder are known to be at high risk of premature
death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above …

Social adaptation requires specific cognitive and emotional competences. Individuals with
high-functioning autism or with Asperger syndrome cannot understand or engage in social …

Background Individuals with autism spectrum disorders (ASDs) often display symptoms from
other diagnostic categories. Studies of clinical and psychosocial outcome in adult patients …

Bipolar affective disorder (BPAD) is a multifactorial disorder with various clinical presentations.
Etiologic heterogeneity may partly underlie the phenotypic heterogeneity. Efforts to …

Background Cannabis use is associated with increased risk of later psychotic disorder but
whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of …