Khat chewing is deeply rooted in the every day life of people living in the Horn of Africa and
in South Arabia, where Catha edulis is endemic. Considered little more than an exotic habit …

Cocaine self-administration decreases type 5 metabotropic glutamate receptor (mGluR5)
tissue concentrations in laboratory rats during early abstinence. These changes are thought to …

Background: Accumulating evidence indicates that drug-related cues can induce dopamine
(DA) release in the striatum of substance abusers. Whether these same cues provoke DA …

Background Glutamate transmission is implicated in drug-induced behavioural sensitization
and the associated long-lasting increases in mesolimbic output. Metabotropic glutamate …

We have previously reported that repeated administrations of quinpirole, a D2/D3 dopamine
receptor agonist, facilitate instrumental behavior in rats given the choice between operant …

Rationale Repeated administrations of the D2/D3 agonist quinpirole (QNP) to rats elicit an
antieconomical pattern of drinking called “contrafreeloading” (CFL), a putative model of …

Rationale Repeated administration of the dopamine D2/D3 agonist quinpirole (QNP)
progressively increases non-regulatory water intake. This effect may model psychotic polydipsia, a …

Rationale Quinpirole (QNP), a D2/D3 dopaminergic receptor agonist, was found to elicit an
apparently antieconomical drinking behavior called contrafreeloading (CFL). The …

We have previously found that repeated exposure to heroin reduces liver synthesis of
morphine-3-glucuronide (M3G) and increases the production of morphine-6-glucuronide (M6G), …

It was suggested in 1986 that cue-induced cocaine craving increases progressively during
early abstinence and remains high during extended periods of time. Clinical evidence now …