C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic inflammation …

Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …

… Since there is substantial overlap of etiological factors across all types of severe mental
illness (Uher & Zwicker, 2017), we include evidence on the entire spectrum of psychotic …

Importance Establishing genetic contributions to the transmission of bipolar disorder (BD)
from parents to offspring may inform the risk of developing this disorder and further serve to …

Background Anxiety disorders are common and impairing throughout the life course.
Propensity to anxiety disorders manifests as distress and avoidance of novel stimuli (called …

Background Attention‐deficit/hyperactivity disorder (ADHD) and lower cognitive ability have
been linked with increased likelihood of exposure to adversity. We hypothesized that these …

BackgroundPsychotic symptoms are common in children and adolescents and may be early
manifestations of liability to severe mental illness (SMI), including schizophrenia. SMI and …

Background Inflammation may play an important role in depression and its treatment. A previous
study found that increased C-reactive protein (CRP), a marker of systemic inflammation, …

Affective lability, defined as the propensity to experience excessive and unpredictable changes
in mood, has been proposed as a potential transdiagnostic predictor of major mood and …

Objective: Family history is an established risk factor for mental illness. The authors sought
to investigate whether polygenic scores (PGSs) can complement family history to improve …