Studies on synaptic plasticity in the context of learning have been dominated by the view that
a single, particular type of plasticity forms the underlying mechanism for a particular type of …

The inferior olive, which provides the climbing fibers to Purkinje cells in the cerebellar cortex,
has been implicated in various functions, such as learning and timing of movements, and …

Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

Several microtubule binding proteins, including CLIP-170 (cytoplasmic linker protein-170),
CLIP-115, and EB1 (end-binding protein 1), have been shown to associate specifically with …

CLIP-170 and CLIP-115 are cytoplasmic linker proteins that associate specifically with the
ends of growing microtubules and may act as anti-catastrophe factors. Here, we have isolated …

Cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses can undergo postsynaptically
expressed long-term depression (LTD) or long-term potentiation (LTP) depending on whether or …

The small GTPase Rab6a is involved in the regulation of membrane traffic from the Golgi
apparatus towards the endoplasmic reticulum (ER) in a coat complex coatomer protein I (COPI)-…

Cerebellar long-term depression (LTD) is a model system for neuronal information storage
that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed …

Fluorescent calcium indicator proteins, such as GCaMP3, allow imaging of activity in genetically
defined neuronal populations. GCaMP3 can be expressed using various gene delivery …

Two of the most striking properties of the cerebellum are its control in timing of motor operations
and its ability to adapt behavior to new sensorimotor associations. Here, we propose a ‘…