Background Anxiety disorders are common and impairing throughout the life course.
Propensity to anxiety disorders manifests as distress and avoidance of novel stimuli (called …

Background Attention‐deficit/hyperactivity disorder (ADHD) and lower cognitive ability have
been linked with increased likelihood of exposure to adversity. We hypothesized that these …

Importance Although anxiety disorders are known to run in families, the relative contribution
of genes and environment is unclear. Patterns of sex-specific transmission of anxiety may …

Major depressive, bipolar, or psychotic disorders are preceded by earlier manifestations in
behaviours and experiences. We present a synthesis of evidence on associations between …

BackgroundCross-sectional studies report high levels of depressive symptoms during the
COVID-19 pandemic, especially in youth and females. However, longitudinal research …

Affective lability, defined as the propensity to experience excessive and unpredictable changes
in mood, has been proposed as a potential transdiagnostic predictor of major mood and …

Severe mental illness (SMI) refers to impairing and frequently chronic disorders that are
difficult to treat. Lower cognitive performance early in life may be a manifestation of risk for SMI. …

Background: Cortical folding is essential for healthy brain development. Previous studies
have found regional reductions in cortical folding in adult patients with psychotic illness. It is …

Background Cognitive impairment is a feature of severe mental illness (SMI; schizophrenia,
bipolar disorder, major depressive disorder). Psychotic forms of SMI may be associated with …

BackgroundBasic symptoms, defined as subjectively perceived disturbances in thought,
perception and other essential mental processes, have been established as a predictor of …