Background: It has been suggested that individuals predisposed to or recovered from
anorexia nervosa experience a hyperserotonergic state associated with anxiety that might be …

Lesch–Nyhan disease (LND) is caused by deficiency of the purine salvage enzyme
hypoxanthine-guanine phosphoribosyltransferase (HPRT). Affected individuals exhibit over-…

• Chilling triggers rapid molecular responses that permit the maintenance of plant cell
homeostasis and plant adaptation. Recent data showed that nitric oxide (NO) is involved in plant …

Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or
prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and …

We postulated that adenosine function could be related to some of the neurological features
of Lesch–Nyhan syndrome and therefore characterized adenosine transport in PBLs (…

The cadherin gene CELSR1 is specifically expressed in the brain and located on chromosome
22q13. 33, a region that has recently been shown to be involved in the etiopathogenesis …

Influenza viruses (IVs) tend to rapidly develop resistance to virus-directed vaccines and
common antivirals targeting pathogen determinants, but novel host-directed approaches might …

Gene targeting approaches greatly facilitate insight into the functioning of monoamine
transporters, the targets of potent antidepressants. The serotonin transporter (5-HTT) is the …

First line pain relief medication during pregnancy relies nearly entirely on the over-the-counter
analgesic acetaminophen, which is generally considered safe to use during gestation. …

Multiple lines of evidence suggest that the endocannabinoid system is implicated in the
development of alcohol dependence. In addition, in animal models, the cannabinoid receptor 1 …