Assessment of executive functions: Review of instruments and identification of critical issues

RCK Chan, D Shum, T Toulopoulou… - Archives of clinical …, 2008 - academic.oup.com
“Executive functions” is an umbrella term for functions such as planning, working memory,
inhibition, mental flexibility, as well as the initiation and monitoring of action. The impairment of …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

…, VJ Carr, D Castle, SV Catts, KD Chambert, RCK Chan… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

[PDF][PDF] Modeling linkage disequilibrium increases accuracy of polygenic risk scores

…, N Carrera, SV Catts, KD Chambert, RCK Chan… - The american journal of …, 2015 - cell.com
Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

[HTML][HTML] Clozapine alone versus clozapine and risperidone with refractory schizophrenia

…, AE Thornton, EYH Chen, RCK Chan… - … England Journal of …, 2006 - Mass Medical Soc
Background The treatment of schizophrenia with multiple antipsychotic drugs is common,
but the benefits and risks are not known. Methods In a randomized, double-blind study, we …

Neurological soft signs in schizophrenia: a meta-analysis

RCK Chan, T Xu, RW Heinrichs, Y Yu… - Schizophrenia …, 2010 - academic.oup.com
Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes
for schizophrenia, but their prevalence and relations with clinical and demographic data are …

[PDF][PDF] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

…, N Carrera, SV Catts, KD Chambert, RCK Chan… - The American Journal of …, 2014 - cell.com
Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

Cross-cultural validation of the depression anxiety stress scale–21 in China.

…, DL Neumann, DHK Shum, RCK Chan - Psychological …, 2016 - psycnet.apa.org
The gap between the demand and delivery of mental health services in mainland China can
be reduced by validating freely available and psychometrically sound psychological …

Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD

…, W Kuang, M Du, S Lui, Q Yue, RCK Chan… - Journal of Psychiatry and …, 2013 - jpn.ca
Background: Many studies using diffusion tensor imaging (DTI) have demonstrated impaired
white matter integrity in patients with major depressive disorder (MDD), with significant …

A meta-analysis of working memory impairments in autism spectrum disorders

…, DHK Shum, T van Amelsvoort, RCK Chan - Neuropsychology …, 2017 - Springer
Autism spectrum disorders (ASD) are characterized by executive dysfunction, and working
memory (WM) comprises one core component of executive function. Many studies have …

Neuropsychological measures of executive function and antisocial behavior: A meta‐analysis

JM Ogilvie, AL Stewart, RCK Chan, DHK Shum - Criminology, 2011 - Wiley Online Library
A meta‐analysis was performed to quantify the association between antisocial behavior (ASB)
and performance on neuropsychological executive functioning (EF) measures. This meta‐…