User profiles for Sebastiaan K.E. Koekkoek

SKE Koekkoek

Erasmus MC
Verified email at erasmusmc.nl
Cited by 5687

[HTML][HTML] Anatomical pathways involved in generating and sensing rhythmic whisker movements

…, C Ju, W Gong, SKE Koekkoek… - Frontiers in integrative …, 2011 - frontiersin.org
The rodent whisker system is widely used as a model system for investigating sensorimotor
integration, neural mechanisms of complex cognitive tasks, neural development, and robotics…

Timing in the cerebellum: oscillations and resonance in the granular layer

E D'Angelo, SKE Koekkoek, P Lombardo, S Solinas… - Neuroscience, 2009 - Elsevier
The brain generates many rhythmic activities, and the olivo-cerebellar system is not an
exception. In recent years, the cerebellum has revealed activities ranging from low frequency to …

Spatiotemporal firing patterns in the cerebellum

…, M Schonewille, L Witter, SK Koekkoek - Nature Reviews …, 2011 - nature.com
Neurons are generally considered to communicate information by increasing or decreasing
their firing rate. However, in principle, they could in addition convey messages by using …

[PDF][PDF] Expression of a protein kinase C inhibitor in Purkinje cells blocks cerebellar LTD and adaptation of the vestibulo-ocular reflex

CI De Zeeuw, C Hansel, F Bian, SKE Koekkoek… - Neuron, 1998 - cell.com
Cerebellar long-term depression (LTD) is a model system for neuronal information storage
that has an absolute requirement for activation of protein kinase C (PKC). It has been claimed …

L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns

…, R Willemsen, SKE Koekkoek… - Human molecular …, 1998 - academic.oup.com
L1 is a neural cell adhesion molecule mainly involved in axon guidance and neuronal
migration during brain development. Mutations in the human L1 gene give rise to a complex …

[PDF][PDF] Evolving models of pavlovian conditioning: cerebellar cortical dynamics in awake behaving mice

…, P Wulff, ACHG IJpelaar, SKE Koekkoek… - Cell reports, 2015 - cell.com
Three decades of electrophysiological research on cerebellar cortical activity underlying
Pavlovian conditioning have expanded our understanding of motor learning in the brain. …

[HTML][HTML] Cerebellar control of gait and interlimb coordination

…, RM Seepers, C Strydis, SKE Koekkoek… - Brain Structure and …, 2015 - Springer
Synaptic and intrinsic processing in Purkinje cells, interneurons and granule cells of the
cerebellar cortex have been shown to underlie various relatively simple, single-joint, reflex types …

[HTML][HTML] Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model

HJ Boele, SKE Koekkoek, CI De Zeeuw - Frontiers in Cellular …, 2010 - frontiersin.org
Over the past decade the advent of mouse transgenics has generated new perspectives on
the study of cerebellar molecular mechanisms that are essential for eyeblink conditioning. …

Encoding of whisker input by cerebellar Purkinje cells

LWJ Bosman, SKE Koekkoek, J Shapiro… - The Journal of …, 2010 - Wiley Online Library
The cerebellar cortex is crucial for sensorimotor integration. Sensorimotor inputs converge
on cerebellar Purkinje cells via two afferent pathways: the climbing fibre pathway triggering …

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

…, J Levenga, HC Van der Linde, SK Koekkoek… - Neurobiology of …, 2008 - Elsevier
Lack of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most
common form of inherited mental retardation. FMRP is an RNA-binding protein and is a …