Normal male human subjects ingested amino acid mixtures which were tryptophan-free,
balanced or contained excess tryptophan. The tryptophan-free mixture causes a marked …

For the last 4 decades, the question of how to manipulate the serotonergic system with drugs
has been an important area of research in biological psychiatry, and this research has led …

Current methods of assessment in clinical psychopharmacology have several serious
disadvantages, particularly for the study of social functioning. We aimed to review the strengths …

Alterations in brain tryptophan levels cause changes in brain serotonin synthesis, and this
has been used to study the implication of altered serotonin levels in humans. In the acute …

PURPOSE: To investigate stress in medical students, law students, and graduate students
at McGill University using a well-validated measure, the Derogatis Stress Profile (DSP). …

OBJECTIVE: Neurotransmission of serotonin (or 5-hydroxytryptamine [5-HT]) is thought to be
disturbed in patients exhibiting impulsive behaviors. However, until recently it has not been …

Methods: A double-blind placebo-controlled cross-over study in which plasma tryptophan was
manipulated by administration of a tryptophan-deficient amino acid mixture. In the placebo …

We investigated (1) the mood response of normal women, without a family history of major
affective disorder, to acute tryptophan depletion, and (2) the temporal stability of the mood …

Tryptophan 5-hydroxyindoleacetic acid and indoleacetic acid were measured in cerebrospinal
fluid taken during pneumoencephalography from patients, some of whom took a 3 g or 6 …

Researchers are not immune to fashion. A wealth of data going back several decades
relating serotonin function to the regulation of mood and the current emphasis on genetics in …