Imaging the serotonin transporter during major depressive disorder and antidepressant treatment: 2005 CCNP Young Investigator Award Paper
JH Meyer - Journal of Psychiatry and Neuroscience, 2007 - jpn.ca
This paper focuses on serotonin transporter 5-HTT imaging to investigate major depressive
disorder (MDD) and antidepressant occupancy. Such investigations have only recently been …
disorder (MDD) and antidepressant occupancy. Such investigations have only recently been …
Serotonin transporter occupancy of high-dose selective serotonin reuptake inhibitors during major depressive disorder measured with [11C]DASB positron emission …
AN Voineskos, AA Wilson, A Boovariwala, S Sagrati… - …, 2007 - Springer
Rationale Previous work has shown 80% serotonin transporter (5-HTT) occupancy to be a
consistent finding at the minimum therapeutic dose during selective serotonin reuptake …
consistent finding at the minimum therapeutic dose during selective serotonin reuptake …
5-HTT Binding in Recovered Depressed Patients and Healthy Volunteers: A Positron Emission Tomography Study With [ 11 C]DASB
Z Bhagwagar, N Murthy, S Selvaraj… - American Journal of …, 2007 - Am Psychiatric Assoc
Objective: The serotonin transporter (5-HTT) is a key target for selective serotonin reuptake
inhibitors and may be involved in the pathophysiology of major depression. It is now …
inhibitors and may be involved in the pathophysiology of major depression. It is now …
Occupancy of Serotonin Transporters by Paroxetine and Citalopram During Treatment of Depression: A [11C]DASB PET Imaging Study
OBJECTIVE: Selective serotonin reuptake inhibitors are commonly used to treat major
depression; however, the percentage of serotonin (5-HT) transporter (5-HTT) sites occupied …
depression; however, the percentage of serotonin (5-HT) transporter (5-HTT) sites occupied …
Diminished brain 5-HT transporter binding in major depression: a positron emission tomography study with [11C]DASB
S Selvaraj, N Venkatesha Murthy, Z Bhagwagar… - …, 2011 - Springer
Background The serotonin transporter (5-HTT) plays a critical role in the regulation of
serotonin neurotransmission and has been implicated in the pathophysiology of major …
serotonin neurotransmission and has been implicated in the pathophysiology of major …
Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C] DASB; comparison with bipolar disorder
DM Cannon, M Ichise, D Rollis, JM Klaver… - Biological …, 2007 - Elsevier
BACKGROUND: Altered serotonergic function is thought to play a role in the
pathophysiology of major depressive episodes based upon evidence from neuroimaging …
pathophysiology of major depressive episodes based upon evidence from neuroimaging …
Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB
S Houle, N Ginovart, D Hussey, JH Meyer… - European journal of …, 2000 - Springer
Two novel radioligands, N, N-dimethyl-2-(2-amino-4-methoxyphenylthio) benzylamine
(DAPP) and (N, N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine (DASB), were …
(DAPP) and (N, N-dimethyl-2-(2-amino-4-cyanophenylthio) benzylamine (DASB), were …
PET brain imaging with [11C](+) McN5652 shows increased serotonin transporter availability in major depression
M Reivich, JD Amsterdam, DJ Brunswick… - Journal of affective …, 2004 - Elsevier
Background: Alterations in the brain serotonin (5-HT) system have been found in patients
with depression. We used the selective 5-HT transporter site ligand [11C](+) McN5652 and …
with depression. We used the selective 5-HT transporter site ligand [11C](+) McN5652 and …
Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl …
J Hirvonen, H Karlsson, J Kajander… - International Journal …, 2008 - academic.oup.com
Abstract Serotonin (5-HT) is involved in the pathophysiology of major depressive disorder
(MDD). Among the numerous serotonergic receptors, the 5-HT1A receptor subtype is of …
(MDD). Among the numerous serotonergic receptors, the 5-HT1A receptor subtype is of …
Sex differences in diencephalon serotonin transporter availability in major depression
JK Staley, G Sanacora, G Tamagnan… - Biological …, 2006 - Elsevier
BACKGROUND: Major depression is more prevalent in women than men. The present study
evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) …
evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) …
