For the last 4 decades, the question of how to manipulate the serotonergic system with drugs
has been an important area of research in biological psychiatry, and this research has led to …

The “serotonin hypothesis” of clinical depression is almost 50 years old. At its simplest, the
hypothesis proposes that diminished activity of serotonin pathways plays a causal role in the …

Serotonin systems appear to play a key role in the pathophysiology of major depressive
disorder. Consequently, ongoing research determines whether serotonin related genes …

The mechanism of action of selective serotonin reuptake inhibitors (SSRIs) involves the
blocking of the neuronal serotonin transporter (5-HTT). The human 5-HTT is encoded by a …

Context The biological basis for the development of major depressive disorder (MDD)
remains incompletely understood. Objective To quantify brain serotonin (5 …

A genetic predisposition to depression may be a potential risk factor in the development of
depression. Although the neurobiological equivaLent of the predisposition remains unclear …

The serotonin hypothesis of depression is still influential. We aimed to synthesise and
evaluate evidence on whether depression is associated with lowered serotonin …

Abstract Serotonin (5-HT) continues to attract researchers' interest after almost a century.
However, despite these efforts, its role has not yet been fully elucidated. It is now evident that …

In the last few years there has been a marked increase in knowledge regarding the possible
roles of serotonin neuronal dysfunction in the patho physiology and treatment of anxiety and …

Substantial evidence supports a role for dysfunction of brain serotonergic (5-HT) systems in
the pathogenesis of major affective disorder, both unipolar (recurrent major depression) and …