Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness

V Drobinin, H Van Gestel, A Zwicker… - Journal of Psychiatry and …, 2020 - jpn.ca
Background: Cortical folding is essential for healthy brain development. Previous studies
have found regional reductions in cortical folding in adult patients with psychotic illness. It is …

Psychotic like experiences in healthy adolescents are underpinned by lower fronto-temporal cortical gyrification: a study from the IMAGEN consortium

R Maitra, CM Horne, O O'Daly… - Schizophrenia …, 2023 - academic.oup.com
Abstract Background and Hypothesis Psychotic Like Experiences (PLEs) are widely
prevalent in children and adolescents and increase the risk of developing psychosis …

Disorganized gyrification network properties during the transition to psychosis

T Das, S Borgwardt, DJ Hauke, F Harrisberger… - JAMA …, 2018 - jamanetwork.com
Importance There is urgent need to improve the limited prognostic accuracy of clinical
instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis …

Reduced brain cortical folding in schizophrenia revealed in two independent samples

R Nesvåg, M Schaer, UK Haukvik, LT Westlye… - Schizophrenia …, 2014 - Elsevier
The cerebral cortex is highly convoluted, and principal folding patterns are determined early
in life. Degree of cortical folding in adult life may index aberrations in brain development …

Increased parietal and occipital lobe gyrification predicts conversion to syndromal psychosis in a clinical high-risk cohort

R Basavaraju, J France, HC Sigmon, RR Girgis… - Schizophrenia …, 2023 - Elsevier
Background Local gyrification index (lGI), indicative of the degree of cortical folding is a
proxy marker for early cortical neurodevelopmental abnormalities. We studied the difference …

Cortical gyrification, psychotic-like experiences, and cognitive performance in nonclinical subjects

U Evermann, C Gaser, B Besteher… - Schizophrenia …, 2020 - academic.oup.com
Background Psychotic-like experiences (PLE) are present in nonclinical populations, yet
their association with brain structural variation, especially markers of early …

Cortical morphometry in the psychosis risk period: a comprehensive perspective of surface features

KSF Damme, T Gupta, R Nusslock, JA Bernard… - Biological Psychiatry …, 2019 - Elsevier
Background Gyrification features reflect brain development in the early prenatal
environment. Clarifying the nature of these features in psychosis can help shed light on the …

Increased occipital gyrification and development of psychotic disorders in individuals with an at-risk mental state: a multicenter study

D Sasabayashi, Y Takayanagi, T Takahashi, S Koike… - Biological …, 2017 - Elsevier
Background Anomalies of brain gyrification have been reported in schizophrenia, possibly
reflecting its neurodevelopmental pathology. However, it remains elusive whether …

Cortical folding defects as markers of poor treatment response in first-episode psychosis

L Palaniyappan, TR Marques, H Taylor… - JAMA …, 2013 - jamanetwork.com
Importance At present, no reliable predictors exist to distinguish future responders from
nonresponders to treatment during the first episode of psychosis. Among potential …

Abnormal cortical folding in high-risk individuals: a predictor of the development of schizophrenia?

JM Harris, H Whalley, S Yates, P Miller… - Biological …, 2004 - Elsevier
BACKGROUND: A number of studies have found localized differences in the appearance
and extent of cortical folding between the brains of schizophrenic patients and healthy …