Psychopharmacology for the Clinician Columns summarize the evidence on a topic of clinical interest. The columns are usually based on a case report in clinical psychopharmacology. The information in the columns is not intended as a definitive treatment strategy but as a suggested approach for clinicians treating patients with similar histories. Individual cases may vary and should be evaluated carefully before treatment is provided.
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2020
Mu-opioid antagonism in the treatment of cannabis use disorder
O. Kebir, X. Laqueille, F. Mouaffak
Kleptomania treated with naltrexone in a patient with intellectual disability
F. Mouaffak, S. Hamzaoui, O. Kebir, X. Laqueille
2019
Treatment of first-episode psychosis in patients with autism-spectrum disorder and intellectual deficiency
N. Garel, R. Joober
Management of sexual adverse effects induced by atypical antipsychotic medication
L. Downing, D.D. Kim, R.M. Procyshyn, P. Tibbo
N-Acetylcysteine augmentation in refractory obsessive–compulsive disorder
S. Bhaskara
Treating resistant depression with 2 forms of convulsive therapy: a clinical case study
A.A. Daskalakis, Z.J. Daskalakis
Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatment
D.D. Kim, A.M. Barr, R.F. White, W.G. Honer, R.M. Procyshyn
2018
Social anxiety disorder in schizophrenia: a neglected, yet potentially important comorbidity
M. Roy, M. Demers, A.M. Achim
Managing disruptive behaviour in autism-spectrum disorder with guanfacine
L. Propper
Covert dysphagia and recurrent pneumonia related to antipsychotic treatment
J.T. Stewart
Pharmacological management of neuropsychiatric symptoms in patients with major neurocognitive disorders
D. Elie, S. Rej
Clozapine, elevated heart rate and QTc prolongation
D.D. Kim, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn
2017
Treatment of ADHD in patients with bipolar disorder
R. Girard, R. Joober
Treating delayed sleep–wake phase disorder in young adults
D.B. Boivin
Recognition and management of antidepressant discontinuation syndrome
V. Bhat, S.H. Kennedy
Pharmacotherapy of trichotillomania
V. Sharma
Generic formulations of psychotropic medications and treatment response
V. Bhat, H.C. Margolese
Refractory social anxiety disorder
M. Van Ameringen, B. Patterson
2016
Clozapine for the management of persistent catatonia
K. Tabbane, S. Halayem, R. Joober
Managing the comorbidity of schizophrenia and ADHD
A. Gough, J. Morrison
Elevated clozapine plasma concentration secondary to a urinary tract infection: proposed mechanisms
L.H.N. Lee, R.F. White, A.M. Barr, W.G. Honer, R.M. Procyshyn
Breakthrough symptoms after switching long-acting injectable paliperidone palmitate from the gluteal to the deltoid site of administration
R.M. Procyshyn, J.L. Banasch, A.M. Barr, W.G. Honer
Treating comorbid premenstrual dysphoric disorder in women with bipolar disorder
M. Smith, B.N. Frey
Successful management of clozapine adverse effects with extended (alternate day) antipsychotic dosing in a patient with schizophrenia
V. Kumar, L. Sharma, S. Madival, G. Venkatasubramanian
2015
Treatment-resistant depression in later life
H. El Bayoumi, Z. Ismail
Topiramate augmentation in a patient with obsessive–compulsive disorder
M. Van Ameringen, B. Patterson
Acute renal and neurotoxicity in older lithium users: How can we manage and prevent these events in patients with late-life mood disorders?
V. Laliberté, C. Yu, S. Rej
Inappropriate benzodiazepine use in elderly patients and its reduction
C. Tannenbaum
Adjunctive treatment with melatonin receptor agonists for older delirious patients with the sundowning phenomenon
T.-C. Yeh, C.-B. Yeh, N.-S. Tzeng, W.-C. Mao
Add-on lithium for the treatment of unipolar depression: Too often forgotten?
F. Jollant
2014
Clozapine augmentation with amisulpride
S. Porcelli, A. Serretti, O. Bianchini
Major depressive disorder and cognitive impairment
R.S. McIntyre
The treatment of bipolar patients with elevated impulsivity and suicide risk
M.E. Sloan, A. Iskric, N.C. Low
Managing ADHD and disruptive behaviour disorders with combination psychostimulant and antipsychotic treatment
D. Elbe, A.M. Barr, W.G. Honer, R.M. Procyshyn
Assessment of adult attention-deficit/ hyperactivity disorder
V. Bhat, J. Paris
Off-label antipsychotic use and tardive dyskinesia in at-risk populations: new drugs with old side effects
G. Remington, M. Hahn
2013
Mixed depression in the postpartum period: diagnostic and treatment issues
V. Sharma
Management strategies for SSR-Iinduced sexual dysfunction
S. J. Rizvi, S.H. Kennedy
Management of clozapine-induced fever: a case of continued therapy throughout fever
N. Martin, R. Williams
Diagnosis and management of periodic catatonia
W.M. Hervey, J.T. Stewart, G. Catalano
Antidepressants and QTc prolongation
R.W. Lam
SSRIs in a case of selective mutism
K. Manassis, D. Avery
2012
Management of comorbid Tourette syndrome and attentiondeficit/ hyperactivity disorder: Are psychostimulants an option?
T. Pringsheim
Antidepressant medication to treat anxiety in patients with bipolar disorder
S. Hassel, G. MacQueen
Prophylaxis and treatment of bipolar disorder in older adults
C.L. Allan, K.P. Ebmeier
Will lithium damage my kidneys?
T.J. Raedler
Managing pathologic aggression in people with psychotic disorders
D. Bourget, A. Labelle
Adverse events associated with switching antipsychotics
J. Su, A.M. Barr, R.M. Procyshyn
2011
Discontinuation of lithium because of side effects
T. Hajek, M. Alda, P. Grof
Bright light for nonseasonal depression?
S.N. Young
Managing anxiety and depressive symptoms in adults with autism-spectrum disorders
K. Boyd, M. Woodbury-Smith, P. Szatmari
Identification and management of cryptic bipolarity in patients with TRD
V. Sharma
Treatment of ADHD in patients unresponsive to methylphenidate
L. Hechtman
Myoclonus as an indicator of infection in patients with schizophrenia treated with clozapine
C.-S. Liang, T.-H. Hsieh
2010
Is there a role for estrogen in treating depression during menopause?
C.N. Soares, B.N. Frey
Autism spectrum disorders, schizo phrenia and diagnostic confusion
M.R. Woodbury-Smith, K. Boyd, P. Szatmari
Options for the treatment of febrile catatonia
G. Northoff
The overdiagnosis of bipolar disorder
I. Iordache, N.C. Low
Tryptophan for refractory bipolar spectrum disorder and sleep-phase delay
R.G. Cooke, R.D. Levitan
Treatment of bipolar disorder with comorbid migraine
A. Ortiz, M. Alda
2009
Should we treat patients with very mild Alzheimer disease with a cholinesterase inhibitor?
S. Gauthier
Treatment of insomnia in posttraumatic stress disorder
N.J. Coupland
Bariatric surgery in patients with bipolar disorder: an emerging issue
V.H. Taylor, M. Misra
Treatment of comorbid tobacco use in people with serious mental illness
K. Lising-Enriquez, T.P. George
Do serum lipids predict response to clozapine treatment?
R.M. Procyshyn, W.G. Honer, A.M. Barr
Optimal use of antidepressants: When to act?
P. Blier
2008
Implementing antiobesity treatment in a patient with a mood disorder
V.H. Taylor
Smoking cessation: the psychiatrist’s role
N.J. Delva
Treating depression during pregnancy
M. Steiner
Subacute alteration in level of consciousness in a woman with psychotic depression
Z. Samaan, G. MacQueen
Combined antidepressants and CBT for panic disorder with agoraphobia
N.J. Coupland
Fish oils for depression?
S.N. Young
2007
Sitting on the edge: when to treat symptoms of inattention without the full DSM-IV criteria of ADHD
R. Joober
Pharmacological treatment of poststroke pathological laughing and crying
P. Giacobbe, A. Flint
Using psychostimulants for treating residual symptoms in major depression
M.T. Berlim, G. Turecki
L-Tyrosine to alleviate the effects of stress?
S.N. Young
Onset of confusion in the context of late-life depression
B.H. Mulsant
Management of conventional antipsychotic-induced tardive dyskinesia
H.C. Margolese, F. Ferreri
2006
Metabolic syndrome: relevance to antidepressant treatment
P. Chokka, M. Tancer, V.K. Yeragani
Psychopharmacology of smoking cessation in patients with mental illness
P. Selby
Treating depression with selective norepinephrine reuptake inhibitors
P. Blier
The rational use of medications in acute psychotic presentations — the case for less is more
A.G. Awad
Treatment guidelines for mania
S.H. Kennedy
Managing discontinuation syndrome in patients with dementia
S. Gauthier
2005
What is the role of pharmacotherapy in the treatment of anorexia nervosa?
M. Israël
What is the best way to treat bipolar depression?
P. Silverstone
What are the treatment options for comorbid alcohol abuse and depressive disorders?
M. Dongier
Selective serotonin reuptake inhibitors (SSRIs) and depression after myocardial infarction (MI)
J.M. Le Mellédo, J. Perez-Parada
What is the optimal implementation of bright light therapy for seasonal affective disorder (SAD)?
Robert D. Levitan