Neuroimaging and genetics of borderline personality disorder: a review

Neuroimaging and genetics of borderline personality disorder: a review

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J Psychiatry Neurosci 2007;32(3):162-73

Eric Lis, BSc; Brian Greenfield, MD; Melissa Henry, PhD; Jean Marc Guilé, MD; Geoffrey Dougherty, MD

Lis, Greenfield, Henry — Faculty of Medicine, McGill University; Greenfield, Dougherty — Montréal Children’s Hospital; Guilé— Douglas Hospital, Montréal, Que.

Abstract

Borderline personality disorder (BPD) is a highly prevalent psychiatric disorder that carries a severe risk factor for adolescent and young adult suicide. Relatively little research has examined its biological etiology. Differences in the volume and activity in brain structures related to emotion and impulsivity have been observed between individuals who have BPD and those who do not. The present study seeks to assess current research on the neuroanatomical differences observed between individuals with and without BPD and the genes that may play a role in the development of this disorder.

Résumé

Le trouble de la personnalité limite (TPL) est une affection psychiatrique très répandue qui comporte un facteur de risque grave de suicide chez les adolescents et les jeunes adultes. Il s’est fait relativement peu de recherche sur son étiologie biologique. On a observé des différences entre les sujets aux prises avec le TPL et ceux qui n’en sont pas atteints au niveau du volume et de l’activité de structures du cerveau reliées à l’émotion et à l’impulsivité. La présente étude vise à évaluer la recherche courante sur les différences neuro-anatomiques observées entre des sujets avec et sans TPL, ainsi que sur les gènes qui peuvent intervenir dans le développement de ce trouble.


Medical subject headings: diagnostic imaging, genetics, personality disorder.

Competing interests: None declared.

Acknowledgements: We acknowledge McGill University and the Canadian Institutes of Health Research (CIHR) for funding this project via the CIHR Health Professional Student Research bursary.

Contributors: Mr. Lis and Dr. Greenfield designed the study. Mr. Lis and Drs. Greenfield and Guilé acquired the data; Mr. Lis, Ms. Henry and Dr. Dougherty analyzed the data. Dr. Lis and Dr. Greenfield wrote the article, and all authors revised it. All authors gave final approval for the article to be published.

Submitted Aug. 15, 2006; Revised Oct. 14, 2006; Accepted Oct. 30, 2006

Correspondence to: Eric Lis, Faculty of Medicine, McGill University, 144 Fairview, Montréal QC H9A 1V6; fax 514 412-4250; ericlis@hotmail.com