Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder

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J Psychiatry Neurosci 2010; 35(5): 238-246

Luis Guillermo Almeida Montes, MD, MSc, PhD; Josefina Ricardo-Garcell, PhD; Lázaro Barajas De La Torre, PhD; Hugo Prado Alcántara, MD; Reyna Beatriz Martínez García, MD; Antonio Fernández-Bouzas, PhD; David Ávila Acosta, MD

Almeida Montes, Prado Alcántara, Martínez García — Departamento de Investigación del Centro Estatal de Salud Mental, Querétaro; Almeida Montes, Ricardo-Garcell — Departamento de Investigación del Instituto de Nerurobiología de la Universidad Nacional Autónoma de México, Querétaro; Barajas De La Torre — Instituto Tecnológico y de Estudios Superiores de Monterrey, Querétaro; Fernández-Bouzas, Avila Acosta — Departamento de Neuroradiología del Instituto de Nerurobiología Universidad Nacional Autónoma de México, Querétaro, México

Abstract

Background: Magnetic resonance imaging (MRI) studies have shown decreased caudate volumes in individuals with attention deficit hyperactivity disorder (ADHD). However, most of these studies have been carried out in male children. Very little research has been done in adults, and the results obtained in children are difficult to extrapolate to adults. We sought to compare the volume of the caudate of adults with ADHD with that of healthy controls; we also compared these volumes between men and women.

Methods: We performed an MRI scan on 20 adults with ADHD (10 men and 10 women) aged 25–35 years and 20 healthy controls matched by age and sex. We used voxel-based morphometry with the DARTEL algorithm for image analyses. We used the specifically designed Friederichsen, Almeida, Serrano, Cortes Test (FASCT) to measure the severity of ADHD; both the self-reported (FASCT-SR) and the observer (FASCT-O) versions were used.

Results: The statistical parametric map showed a smaller region with low grey matter volume and a smaller concentration of grey matter in this region of the right caudate in ADHD patients than in health controls, both in the entire sample and within each sex. There was a significant correlation between the volume of this region of the caudate with the number of DSM IV-TR criteria, as well as with the total scores and most of the factors of the FASCT-SR and FASCT-O scales. A separate correlation analysis by sex gave similar results.

Limitations: The study design was cross-sectional.

Conclusions: The region of the right caudate with low
grey matter volume was smaller in adults with ADHD in both sexes and was correlated with ADHD severity.


Submitted Aug. 17, 2009; Revised Dec. 28, 2009, Mar. 13, 2010; Accepted Mar. 15, 2010.

Acknowledgments: Secretaria de Salud del Estado de Querétaro, México, and Consej Nacional de Ciencia y Tecnología provided grants for this work. Programa de Doctorado en Ciencias Biomédicas de la Universidad Nacional Autónoma de México provided academic and research guidance.

Competing interests: None declared.

Contributors: Drs. Almeida Montes, Ricardo-Garcell, Prado Alcántara, Martínez García and Fernández-Bouzas designed the study. Drs. Almeida Montes, Prado Alcántara and Ávila Acosta acquired the data, which Drs. Almeida Montes, Ricardo-Garcell, Barajas De La Torre, Prado Alcántara, Martínez García and Fernández-Bouzas analzyed. Drs. Almeida Montes, Ricardo-Garcell, Prado Alcántara and Fernández-Bouzas wrote the article. All authors reviewed the article and approved its publication.

DOI: 10.1503/jpn.090099

Correspondence to: Dr. L.G. Almeida Montes, Departamento de Investigación del Centro Estatal de Salud Mental, Servicios de Salud del Estado de Querétaro & Unidad de Investigación en Neurodesarrollo Dr. Augusto Fernández Guardiola, Instituto de Neurobiología Campus Juriquilla, Querétaro, Universidad Nacional Autónoma de México; almeidal@prodigy.net.mx