July 2005

 J Psychiatry Neurosci 2005;30(4)


Atypical antipsychotics for mood and anxiety disorders: Safe and effective adjuncts?
P. Blier

CCNP News and Views

In memoriam — Pavel Hrdina, MD, PhD (1929-2005)
Y.D. Lapierre, G. Robertson

Review Papers

Neuropsychiatric manifestations of HIV infection and AIDS
B. Dubé, T. Benton, D.G. Cruess, D.L. Evans

Sleep and perinatal mood disorders: a critical review
L.E. Ross, B.J. Murray, M. Steiner

Chromatin, DNA methylation and neuron gene regulation — the purpose of the package
R.P. Sharma, D.R. Grayson, A. Guidotti, E. Costa

Research Papers

Responsiveness of 5-HT1A and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition
M. El Mansari, P. Blier

Evidence for the activity of lamotrigine at 5-HT1A receptors in the mouse forced swimming test
M. Bourin, F. Masse, M. Hascoët

Psychopharmacology for the Clinician

On the selection and use of atypical antipsychotics in the management of nonpsychotic mood and anxiety disorders
P. Blier

January 2006

J Psychiatry Neurosci 2006;31(1)


Discontinuing treatment for psychiatric disorders
R.T. Joffe


Ecological momentary assessment: what it is and why it is a method of the future in clinical psychopharmacology
D.S. Moskowitz, S.N. Young

Review Paper

Brain imaging and cognitive dysfunctions in Huntington’s disease
A. Montoya, B.H. Price, M. Menear, M. Lepage

Research Papers

Antipsychotic drugs cause glial cell line–derived neurotrophic factor secretion from C6 glioma cells
Z. Shao, L.E. Dyck, H. Wang, X.M. Li

Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence
A.J. Dean, J.B. Saunders, R.T. Jones, R.M. Young, J.P. Connor, B.R. Lawford

Efficacy of methylphenidate in children with attention-deficit hyperactivity disorder and learning disabilities: a randomized crossover trial
N. Grizenko, M. Bhat, G. Schwartz, M. Ter-Stepanian, R. Joober

Psychopharmacology for the Clinician

Managing discontinuation syndrome in patients with dementia
S. Gauthier


2005 Reviewers

March 2006

J Psychiatry Neurosci 2006;31(2)


Fewer classes of drugs for more and more psychiatric disorders
L.T. Young

Review Papers

Antidepressant effects of exercise: Evidence for an adult-neurogenesis hypothesis?
C. Ernst, A.K. Olson, J.P.J. Pinel, R.W. Lam, B.R. Christie

The “delayed onset” of antipsychotic action — an idea whose time has come and gone
O. Agid, P. Seeman, S. Kapur

Research Papers

Increased positive emotional memory after repetitive transcranial magnetic stimulation over the orbitofrontal cortex
D.J.L.G. Schutter, J. van Honk

Nuclear factor kappa Β in the dorsal raphe of macaques: an anatomical link for steroids, cytokines and serotonin
C.L. Bethea, A.P. Reddy, L.J. Smith

Alexithymia and stress-induced brain activation in cocaine-dependent men and women
C.S.R. Li, R. Sinha

Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis
S.H. Kennedy, H.F. Andersen, R.W. Lam

Brief Report

The use of medroxyprogesterone acetate for the treatment of sexually inappropriate behaviour in patients with dementia
S.A. Light, S. Holroyd

Psychopharmacology for the Clinician

Treatment guidelines for mania
S.H. Kennedy

September 2005

J Psychiatry Neurosci 2005;30(5)


The Douglas Hospital Research Centre: celebrating 25 years of innovation in mental health research
R. Quirion

Douglas Hospital Research Centre Symposium

Stressed or stressed out: What is the difference?
B.S. McEwen

The Montreal Imaging Stress Task: using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain
K. Dedovic, R. Renwick, N. Khalili Mahani, V. Engert, S.J. Lupien, J.C. Pruessner

The Douglas Hospital Longitudinal Study of Normal and Pathological Aging: summary of findings
S.J. Lupien, G. Schwartz, Y.K. Ng, A. Fiocco, N. Wan, J.C. Pruessner, M.J. Meaney, N.P.V. Nair

Exploring the gene-environment nexus in eating disorders
C.M. Bulik

Understanding putative risk factors for schizophrenia: retropective and prospective studies
S. King, D. Laplante, R. Joober

Genetics of developmental psychiatric disorders: pathways to discovery
R. Joober, S. Sengupta, P. Boksa

Economic considerations associated with assertive community treatment and supported employment for people with severe mental illness
E. Latimer

The national policy reforms for mental health services and the story of early intervention services in the United Kingdom
R. Joseph, M. Birchwood

Psychopharmacology for the Clinician

What is the best way to treat bipolar depression?
P. Silverstone


Neuropsychiatric manifestations of HIV infection and AIDS: correction

May 2006

J Psychiatry Neurosci 2006;31(3)


A rant against jargon and neologisms
S.N. Young

Review Papers

Schizophrenia: an integrative approach to modelling a complex disorder
G.S. Robertson, S.E. Hori, K.J. Powell

The search for new off-label indications for antidepressant, antianxiety, antipsychotic and anticonvulsant drugs
G. Chouinard

Interrelations between psychiatric symptoms and drug-induced movement disorder
G. Chouinard

Research Papers

“Missing links” in borderline personality disorder: loss of neural synchrony relates to lack of emotion regulation and impulse control
L.M. Williams, A. Sidis, E. Gordon, R.A. Meares

Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder
X. Sun, J.F. Wang, M. Tseng, L.T. Young

CCNP News and Views

Canadian College of Neuropsychpharmacology — 2006 Award Winners

Psychopharmacology for the Clinician

The rational use of medications in acute psychotic presentations — the case for less is more
A.G. Awad

July 2006

 J Psychiatry Neurosci 2006;31(4)


Pregnancy, depression, antidepressants and breast-feeding
P. Blier

Review Papers

The role of neurotensin in central nervous system pathophysiology: What is the evidence?
F. St-Gelais, C. Jomphe, L.É. Trudeau

Research Papers

The effect of lithium on the adrenoceptor-mediatedsecond messenger system in the rat brain
R. Devaki, S. Shankar Rao, S.M. Nadgir

Social behaviour and mood in everyday life: the effects of tryptophan in quarrelsome individuals
M. aan het Rot, D.S. Moskowitz, G. Pinard, S.N. Young

Increased olfactory sensitivity in euthymic patients with bipolar disorder with event-related episodes compared with patients with bipolar disorder without such episodes
S. Krüger, J. Frasnelli, P. Bräunig, T. Hummel

Levomepromazine versus chlorpromazine in treatment-resistant schizophrenia: a double-blind randomized trial
S. Lal, J.X. Thavundayil, N.P.V. Nair, L. Annable, N.M.K. Ng Ying Kin, A. Gabriel, G. Schwartz

Psychopharmacology for the Clinician

Treating depression with selective norepinephrine reuptake inhibitors
P. Blier


Efficacy of escitalopram in the treatment of major depressive disorder compared with conventional selective serotonin reuptake inhibitors and venlafaxine XR: a meta-analysis

September 2006

J Psychiatry Neurosci 2006;31(5)


Neurodegeneration and aldehyde load: from concept to therapeutics
P.L. Wood

Review Paper

The need for speed: an update on methamphetamine addiction
A.M. Barr, W.J. Panenka, G.W. MacEwan, A.E. Thornton, D.J. Lang, W.G. Honer, T. Lecomte

Research Papers

Reduced hippocampal volume correlates with executive dysfunctioning in major depression
T. Frodl, A. Schaub, S. Banac, M. Charypar, M. Jäger, P. Kümmler, R. Bottlender, T. Zetzsche, C. Born, G. Leinsinger, M. Reiser, H.J. Möller, E.M. Meisenzal

Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania
B.N. Frey, S.S. Valvassori, G.Z. Réus, M.R. Martins, F.C. Petronilho, K. Bardini, F. Dal-Pizzol, F. Kapczinski, J. Quevedo

Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects
K.Y. Little, L. Zhang, E. Cook

Psychopharmacology for the Clinician

Psychopharmacology of smoking cessation in patients with mental illness
P. Selby

November 2005

J Psychiatry Neurosci 2005;30(6)


Cardiac risk and schizophrenia
R. Jindal, E.M. MacKenzie, G.B. Baker, V.K. Yeragani

Review papers

Dissecting the suicide phenotype: the role of impulsive–aggressive behaviours
G. Turecki

Augmentation of olanzapine in treatment-resistant schizophrenia
M. Zink

Research Papers • Articles de recherche

Proton magnetic resonance spectroscopy of the anterior cingulate gyrus, insular cortex and thalamus in schizophrenia associated with idiopathic unconjugated hyperbilirubinemia (Gilbert’s syndrome)
R. Yasukawa, T. Miyaoka, S. Mizuno, T. Inagaki, J. Horiguchi, K. Oda, H. Kitagaki

Long-term lithium treatment and thyroid antibodies: a controlled study
C. Baethge, H. Blumentritt, A. Berghöfer, T. Bschor, T. Glenn, M. Adli, P. Schlattmann, M. Bauer, R. Finke

Brief reports

Ziprasidone therapy for post-traumatic stress disorder
Z. Siddiqui, W.A. Marcil, S.C. Bhatia, S. Ramaswamy, F. Petty

Modafinil as an adjunctive treatment to sleep deprivation in depression
C. Even, J. Thuile, J. Santos, P. Bourgin

Letters to the Editors

Repetitive transcranial magnetic stimulation for the treatment of depression
F. Fregni, A. Pascual-Leone

Response from author
J. Couturier

CCNP News and Views

The 28th Annual Meeting of the Canadian College of Neuropsychopharmacology
St. John’s, Newfoundland, Canada, July 2–5, 2005

K. Casey, L.K. Srivastava, C. Flores, M. Leyton

Psychopharmacology for the Clinician

What is the role of pharmacotherapy in the treatment of anorexia nervosa?
M. Israël

November 2006

J Psychiatry Neurosci 2006;31(6)


Is the thyroid still important in major depression?
R.T. Joffe

Review Paper

Cognitive dysfunctions in schizophrenia: potential benefits of cholinesterase inhibitor adjunctive therapy
F. Ferreri, C. Agbokou, S. Gauthier

Research Papers

Depression in acute stroke
L. Caeiro, J.M. Ferro, C.O. Santos, M.L. Figueira

Differential effects of naltrexone on cardiac, subjective and behavioural reactions to acute ethanol intoxication
J.B. Peterson, P. Conrod, J. Vassileva, C. Gianoulakis, R.O. Pihl

About the mechanisms of auditory verbal hallucinations: a positron emission tomographic study
M. Stephane, M.C. Hagen, J.T. Lee, J. Uecker, P.J. Pardo, M.A. Kuskowski, J.V. Pardo

Brief report

The relation between peripheral and central glutamate and glutamine in healthy male volunteers
Y. Shulman, S. Grant, P. Seres, C. Hanstock, G. Baker, P. Tibbo

Letters to the Editors

Concerns regarding antidepressant drug use during pregnancy
A.C. Urato

Reply: Practicing medicine on the basis of the unconfirmed and omitting the established facts
Pierre Blier

CCNP News and Views

The 29th Annual Meeting of the Canadian College of Neuropsychopharmacology

Psychopharmacology for the Clinician

Metabolic syndrome: relevance to antidepressant treatment
P. Chokka, M. Tancer, V.K. Yeragani


Psychopharmacology of smoking cessation in patients with mental illness

January 2007

J Psychiatry Neurosci 2007;32(1)


Of rats and schizophrenia
P. Boksa

Research Papers

Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression
B.P. Wann, T.M. Bah, M. Boucher, J. Courtemanche, N. Le Marec, G. Rousseau, R. Godbout

Effects of valproate on serotonin-induced intracellular calcium mobilization in human platelets
T. Akimoto, I. Kusumi, K. Suzuki, T. Masui, T. Koyama

Platelet serotonin levels support depression scores for women with postpartum depression
E. Maurer-Spurej, C. Pittendreigh, S. Misri

Review Papers

Cannabis and cognitive dysfunction: Parallels with endophenotypes of schizophrenia?
N. Solowij, P.T. Michie

Psychopharmacology for the Clinician

Management of conventional antipsychotic-induced tardive dyskinesia
H.C. Margolese, F. Ferreri

March 2007

J Psychiatry Neurosci 2007;32(2)


Folate and depression — a neglected problem
S.N. Young

CCNP News and Views

In memoriam — Guy Debonnel
P. Blier

CCNP Award Paper

Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
J.H. Meyer

Review Paper

NMDA neurotransmission as a critical mediator of borderline personality disorder
B. Grosjean, G.E. Tsai

Brief report

Neurocognitive function in an extended Afrikaner-ancestry family with affective illness
J. Savitz, L. van der Merwe, M. Solms, R. Ramesar

Research Papers

Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese population
C-C Chang, R-B Lu, C-L Chen, C-M Chu, H-A Chang, C-C Huang, Y-L Huang, S-Y Huang

Mood-elevating effects of d-amphetamine and incentive salience: the effect of acute dopamine precursor depletion
M. Leyton, M. ann het Rot, L. Booij, G.B. Baker, S.N. Young, C. Benkelfat

Psychopharmacology for the Clinician

Onset of confusion in the context of late-life depression
B.H. Mulsant

May 2007

J Psychiatry Neurosci 2007;32(3)


Is bipolar disorder a mitochondrial disease?
L.T. Young

Review Paper

Neuroimaging and genetics of borderline personality disorder: a review
E. Lis, B. Greenfield, M. Henry, J. M. Guilé, G. Dougherty

Research Papers

An event-related functional MRI study of working memory in euthymic bipolar disorder
J. Lagopoulos, B. Ivanovski, G.S. Malhi

Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependence
S-Y Huang, W-W Lin, F-J Wan, A-J Chang, H-C Ko, T-J Wang, P-L Wu, R-B Lu

Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats
E.M. Strome, A.P. Zis, D.J. Doudet

Neuron somal size is decreased in the lateral amygdalar nucleus of subjects with bipolar disorder
Y.B. Bezchlibnyk, X. Sun, J-F Wang, G.M. MacQueen, B.S. McEwen, L.T. Young

Psychopharmacology for the Clinician

L-Tyrosine to alleviate the effects of stress?
S.N. Young

July 2007

J Psychiatry Neurosci 2007;32(4)


The usefulness of large studies in psychopharmacology: understanding their strong points and their drawbacks
P. Blier

Research Papers

[I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects
W. Koch, N. Schaaff, G. Pöpperl, C. Mulert, G. Juckel, M. Reicherzer, C. Ehmer-von Geiso, H-J Möller, U. Hegerl, K. Tatsch, O. Pogarell

The long-term impact of treatment with electroconvulsive therapy on discrete memory systems in patients with bipolar disorder
G. MacQueen, C. Parkin, M. Marriott, H. Bégin, G. Hasey

Empirical evaluation of language disorder in schizophrenia
M. Stephane, G. Pellizzer, C.R. Fletcher, K. McClannahan

Cortical excitability and rest activity properties in patients with depression
C. Salustri, F. Tecchio, F. Zappasodi, G. Bevacqua, M. Fontana, M. Ercolani, D. Milazzo, R. Squitti, P.M. Rossini

Visual scan paths in first-episode schizophrenia and cannabis-induced psychosis
P.J. Benson, U. Leonards, R.M. Lothian, D.M. St. Clair, M.C.G. Merlo

CCNP Award Paper

Maternal programming of defensive responses through sustained effects on gene expression
J. Diorio, M.J. Meaney

Psychopharmacology for the Clinician

Using psychostimulants for treating residual symptoms in major depression
M.T. Berlim, G. Turecki

September 2007

J Psychiatry Neurosci 2007;32(5)


Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?
G.B. Baker, B. Sowa, K.G. Todd

Research Papers

Dysfunction in early auditory processing in major depressive disorder revealed by combined MEG and EEG
S. Kähkönen, H. Yamashita, H. Rytsälä, K. Suominen, J. Ahveninen, E. Isometsä

Haloperidol induces the nuclear translocation of phosphatidylinositol 3′-kinase to disrupt Akt phosphorylation in PC12 cells
Y. Dai, Z. Wei, C.F. Sephton, D. Zhang, D.H. Anderson, D.D. Mousseau

Changes in serum lipids, independent of weight, are associated with changes in symptoms during long-term clozapine treatment
R.M. Procyshyn, K.M. Wasan, A.E. Thornton, A.M. Barr, E.Y.H. Chen, E. Pomarol-Clotet, E. Stip, R. Williams, G.W. MacEwan, C.L. Birmingham, W.G. Honer, for the Clozapine and Risperidone Enhancement Study Group

Auditory processing in schizophrenia during the middle latency period (10–50 ms): high-density electrical mapping and source analysis reveal subcortical antecedents to early cortical deficits
V.M. Leavitt, S. Molholm, W. Ritter, M. Shpaner, J.J. Foxe

The 5HTTLPR polymorphism, prior maltreatment and dramatic–erratic personality manifestations in women with bulimic syndromes
H. Steiger, J. Richardson, R. Joober, L. Gauvin, M. Israel, K.R. Bruce, N.M.K.N. Ying Kin, H. Howard, S.N. Young

Fatty acid composition in postmortem brains of people who completed suicide
A. Lalovic, É. Levy, L. Canetti, A. Sequeira, A. Montoudis, G. Turecki

Psychopharmacology for the Clinician

Pharmacological treatment of poststroke pathological laughing and crying
P. Giacobbe, A. Flint

November 2007

J Psychiatry Neurosci 2007;32(6)


How to increase serotonin in the human brain without drugs
S.N. Young

Review Paper

Dopaminergic regulation of limbic-striatal interplay
S.B. Floresco

Research Papers

Association of α4β2 nicotinic receptor and heavy smoking in schizophrenia
S. Voineskos, V. De Luca, A. Mensah, J.B. Vincent, N. Potapova, J.L. Kennedy

Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
N. Rüsch, E. Luders, K. Lieb, R. Zahn, D. Ebert, P.M. Thompson, A.W. Toga, L. Tebartz van Elst

Amygdala reactivity to masked negative faces is associated with automatic judgmental bias in major depression: a 3 T fMRI study
U. Dannlowski, P. Ohrmann, J. Bauer, H. Kugel, V. Arolt, W. Heindel, A. Kersting, B.T. Baune, T. Suslow

Brief Reports

In vivo measurements of brain trapping of 11C-labelled α-methyl-L-tryptophan during acute changes in mood states
E. Perreau-Linck, M. Beauregard, P. Gravel, V. Paquette, J-P Soucy, M. Diksic, C. Benkelfat

Malondialdehyde levels in adult attention-deficit hyperactivity disorder
M. Bulut, S. Selek, H.S. Gergerlioglu, H.A. Savas, H.R. Yilmaz, M. Yuce, G. Ekici

CCNP News and Views

The 30th Annual Meeting of the Canadian College of Neuropsychopharmacology
K.F. Casey, R.J. Beninger, U. Busto, R.E. Tarter, M. Leyton

Psychopharmacology for the Clinician

Sitting on the edge: when to treat symptoms of inattention without the full DSM-IV criteria of ADHD
R. Joober


Auditory processing in schizophrenia during the middle latency period (10–50 ms): high-density electrical mapping and source analysis reveal subcortical antecedents to early cortical deficits