May – June 2021

J Psychiatry Neurosci 2021 May-June;46(3)


The moving target of psychiatric diagnosis
M. Alda

Research Papers

A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss
C.A. Lewis, K. Mueller, R.G. Zsido, J. Reinelt, R. Regenthal, H. Okon-Singer, E.E. Forbes, A. Villringer, J. Sacher

Social support and hippocampal volume are negatively associated in adults with previous experience of childhood maltreatment
K. Förster, L. Danzer, R. Redlich, N. Opel, D. Grotegerd, E.J. Leehr, K. Dohm, V. Enneking, S. Meinert, J. Goltermann, H. Lemke, L. Waltemate, K. Thiel, K. Behnert; K. Brosch, F. Stein, T. Meller, K. Ringwald, S. Schmitt, O. Steinsträter, A. Jansen, A. Krug, I. Nenadic, T. Kircher, T. Hahn, H. Kugel, W. Heindel, J. Repple, U. Dannlowski

Acute conceptual disorganization in untreated first-episode psychosis: a combined magnetic resonance spectroscopy and diffusion imaging study of the cingulum
Y. Pan, K. Dempster, P. Jeon, J. Théberge, A.R. Khan, L. Palaniyappan

Brain cortical and subcortical morphology in adolescents with depression and a history of suicide attempt
A.J. Gifuni, M.M. Chakravarty, M. Lepage, T.C. Ho, M.-C. Geoffroy, E. Lacourse, I.H. Gotlib, G. Turecki, J. Renaud, F. Jollant

Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case–control study
D. Ciocan, A-M. Cassard, L. Becquemont, C. Verstuyft, C.S. Voican, K. El Asmar, R. Colle, D. David, S. Trabado, B. Feve, P. Chanson, G. Perlemuter, E. Corruble

Cortico-cortical connectivity behind acoustic information transfer to mouse orbitofrontal cortex is sensitive to neuromodulation and displays local sensory gating: relevance in disorders with auditory hallucinations?
A. Tripathi, S.S. Sato, P. Medini

Elevated activity in the dorsal dentate gyrus reduces expression of fear memory after fear extinction training
Y. Zhang, Z. Wang, J. Ju, J. Liao, Q. Zhou

Chronic lithium treatment alters the excitatory/ inhibitory balance of synaptic networks and reduces mGluR5–PKC signalling in mouse cortical neurons
A. Khayachi, A. Ase, C. Liao, A. Kamesh, N. Kuhlmann, L. Schorova, B. Chaumette, P. Dion, M. Alda, P. Séguéla, G. Rouleau, A. Milnerwood

Psychopharmacology for the Clinician

Serotonin syndrome: SSRIs are not the only culprit
N. Garel, K.T. Greenway, K. Tabbane, R. Joober

To continue or discontinue antidepressants in anxiety disorders? A dilemma for patients and clinicians
A. Muntingh, N. Batelaan, W. Scholten, A.J. van Balkom

March – April 2021

J Psychiatry Neurosci 2021 March-April;46(2)


Can treatment of obesity reduce depression or vice versa?
S.L. Borgland

Research Papers

Threat-anticipatory psychophysiological response is enhanced in youth with anxiety disorders and correlates with prefrontal cortex neuroanatomy
R. Abend, M.A. Bajaj, A. Harrewijn, C. Matsumoto, K.J. Michalska, E. Necka, E.E. Palacios-Barrios, E. Leibenluft, L.Y. Atlas, D.S. Pine

Reduced visual contrast suppression during major depressive episodes
V. Salmela, L. Socada, J. Söderholm, R. Heikkilä, J. Lahti, J. Ekelund, E. Isometsä

COVID-19 infection causes a reduction in neutrophil counts in patients taking clozapine
S. Gee, D. Taylor

Fatty acid amide hydrolase binding is inversely correlated with amygdalar functional connectivity: a combined positron emission tomography and magnetic resonance imaging study in healthy individuals
D.G.J. Green, J. Kim, S.J. Kish, R.F. Tyndale, M.N. Hill, A.P. Strafella, J. Tong, T. McCluskey, D.J. Westwood, S. Houle, N.J. Lobaugh, I. Boileau

A linkage and exome study of multiplex families with bipolar disorder implicates rare coding variants of ANK3 and additional rare alleles at 10q11-q21
C. Toma, A.D. Shaw, A. Heath, K.D. Pierce, P.B. Mitchell, P.R. Schofield, J.M. Fullerton

Sex differences in innate and adaptive neural oscillatory patterns link resilience and susceptibility to chronic stress in rats
R-K.Thériault, J.D. Manduca, M.L. Perreault

The predictive value of neurobiological measures for recidivism in delinquent male young adults
J. Zijlmans, R. Marhe, F. Bevaart, L. Van Duin, M-J.A. Luijks, I. Franken, H. Tiemeier, A. Popma

Use of levamisole-adulterated cocaine is associated with increased load of white matter lesions
F. Conrad, S. Hirsiger, S. Winklhofer, M.R. Baumgartner, P. Stämpfli, E. Seifritz, S. Wegener, B.B. Quednow

Augmentation of fear extinction by theta-burst transcranial magnetic stimulation of the prefrontal cortex in humans
J. Deng, W. Fang, Y. Gong, Y. Bao, H. Li, S. Su, J. Sun, J. Shi, L. Lu, L. Shi, H. Sun

Multimodal brain imaging connectivity analyses of emotional and motivational deficits in depression among women
G. Robert, E. Bannier, M. Comte, L. Domain, I. Corouge, T. Dondaine, J-M. Batail, J-C. Ferre, E. Fakra, D. Drapier

Psychopharmacology for the Clinician

Binge eating disorder hidden behind a wall of anxiety disorders
A. Pipe, B. Patterson, M. Van Ameringen

Elevated clozapine levels and toxic effects after SARS-CoV-2 vaccination
D. Thompson, C.M. Delorme, R.F. White, W.G. Honer

January – February 2021

J Psychiatry Neurosci 2021 January-February;46(1)


Why did the kitten cross the road? A meditation on positive versus negative reinforcement in addiction
M. Leyton

Review Paper

Precision clinical trials: a framework for getting to precision medicine for neurobehavioural disorders
E.J. Lenze, G.E. Nicol, D.L. Barbour, T. Kannampallil, A.W.K. Wong, J. Piccirillo, A.T. Drysdale, C.M. Sylvester, R. Haddad, J.P. Miller, C.A. Low, S.N. Lenze, K.E. Freedland, T.L. Rodebaugh

Research Papers

Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans
K. Smart, A. Nagano-Saito, M.S. Milella, D.Y. Sakae, M. Favier, E. Vigneault, L. Louie, A. Hamilton, S.S.G. Ferguson, P. Rosa-Neto, S. Narayanan, S. El Mestikawy, M. Leyton, C. Benkelfat

Noninvasive brain stimulation in children and adults with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis
S.J. Westwood, J. Radua, K. Rubia

Uncovering neurodevelopmental paths to autism spectrum disorder through an integrated analysis of developmental measures and neural sensitivity to faces
G. Bussu, A. Llera, E.J.H. Jones, C. Tye, T. Charman, M.H. Johnson, C.F. Beckmann, J.K. Buitelaar

G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease
B. Galet, M. Ingallinesi, J. Pegon, A.D. Thi, P. Ravassard, N.F. Biguet, R. Meloni

Emotional and interpersonal mechanisms in community SSRI treatment of social anxiety disorder
L.M. Rappaport, M.D. Hunter, J.J. Russell, G. Pinard, P. Bleau, D.S. Moskowitz

Confidence in visual motion discrimination is preserved in individuals with schizophrenia
N. Faivre, M. Roger, M. Pereira, V. de Gardelle,  J-C. Vergnaud, C. Passerieux, P. Roux

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach
R. Smith, N. Kirlic, J.L. Stewart, J. Touthang, R. Kuplicki, S. Khalsa, J. Feinstein, M.P. Paulus, R. Aupperle

Cortical inhibition, facilitation and plasticity in late-life depression: effects of venlafaxine pharmacotherapy
J.I. Lissemore, B.H. Mulsant, T.K. Rajji, J.F. Karp, C.F. Reynolds III, E.J. Lenze, J. Downar, R. Chen, Z.J. Daskalakis, D.M. Blumberger

Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder
L-l. Wu, M.N. Potenza, N. Zhou, H. Kober, X-h. Shi, S.W. Yip, J-h. Xu, L. Zhu, R. Wang, G-q. Liu, J-t. Zhang

Suicide risk within 1 year of dementia diagnosis in older adults: a nationwide retrospective cohort study
J.W. Choi, K.S. Lee, E. Han

A voxel-wise meta-analysis of task-based functional MRI studies on impaired gain and loss processing in adults with addiction
Z. Qiu, J. Wang

11β-Hydroxylase (CYP11B1) gene variants and new-onset depression in later life
M. Ancelin, J. Norton, K. Ritchie, I. Chaudieu, J. Ryan

DCC gene network in the prefrontal cortex is associated with total brain volume in childhood
A. Morgunova, I. Pokhvisneva, S. Nolvi, S. Entringer, P. Wadhwa, J. Gilmore, M. Styner, C. Buss, R.B. Sassi, G.B.C. Hall, K.J. O’Donnell, M.J. Meaney, P.P. Silveira, C.A. Flores

The role of anthranilic acid in the increase of depressive symptoms and major depressive disorder during treatment for hepatitis C with pegylated interferon-α2a and oral ribavirin
T. Pawlowski, D. Pawlak, M. Inglot, M. Zalewska, D. Marciniak, J. Bugajska,
J. Janocha-Litwin, K. Malyszczak

Association between depressive symptoms and pulse wave velocity is mediated by increased adiposity in older adults with type 2 diabetes
M. C. Moh, S. Low, T. P. Ng, S. F. Ang, K. Ang, C. F. Sum, T. Subramaniam, S. C. Lim

Effects of childhood adversity on the volumes of the amygdala subnuclei and hippocampal subfields in individuals with major depressive disorder
A. Aghamohammadi-Sereshki, N. J. Coupland, P. H. Silverstone, Y. Huang, K. M. Hegadoren, R. Carter, P. Seres, N. V. Malykhin

Therapeutic benefits of pharmacologic and nonpharmacologic treatments for depressive symptoms after traumatic brain injury: a systematic review and network meta-analysis
Y.-S. Cheng, P.-T. Tseng, Y.-C. Wu, Y.-K. Tu, C.-K. Wu, C.-W. Hsu, W.-T. Lei, D.-J. Li, T.-Y. Chen, B. Stubbs, A. F. Carvalho, C.-S. Liang, T.-C. Yeh, C.-S. Chu, Y.-W. Chen, P.-Y. Lin, M.-K. Wu, C.-K. Sun

Psychopharmacology for the Clinician

The antipsychotic potential of cannabidiol: clinical implications for patients with psychosis and comorbid cannabis use disorder
N. Garel, K.T. Greenway, R. Joober

JPN moves to online only

As of January 2021, the Journal of Psychiatry and Neuroscience (JPN) will move to an online only format, and the print format will be discontinued. JPN content is currently already freely available online. In 2021 the journal moves to a new content licence, making all content Open Access.  We will continue to publish our popular Editorials and Psychopharmacology for the Clinician articles on a bimonthly schedule.

Advantages of online-only publication will include

  • Reduced time from acceptance to publication
  • Immediate publication of finalized copy-edited papers
  • Rapid Open Access to all papers published
  • Rapid indexing of all finalized papers in PubMed and other aggregators
  • Increased impact for papers immediately available in final format
  • No colour fees
  • Increased flexibility for number of papers published.
  • Low publication fee ($Can 2100) for Open Access
  • Rank among the top Open Access journals in biological psychiatry (2018 IF: 4.899)

Sign up for our eTOC at to get regular reminders of our most recent papers.

Consider submitting your work to JPN.  As always, JPN will continue to focus narrowly on papers that provide insight into the neural mechanisms involved in the etiology and treatment of specific psychiatric disorders.  We remain committed to fair and timely peer review of submitted manuscripts, as outlined by Young.

November 2020

J Psychiatry Neurosci 2020;45(6)


Reconsidering brain tissue changes as a mechanistic focus for early intervention in psychiatry
L. Palaniyappan, N. Sukumar

Research Papers

Sex-specific pathways among tri-allelic serotonin transporter polymorphism, trait neuroticism and generalized anxiety disorder
H.-A. Chang, W.-H. Fang, Y.-P. Liu, N.-S. Tzeng, J.-F. Shyu, F.-J. Wan, S.-Y. Huang, T.-C. Chang, C.-C. Chang

Predicting response to psychiatric surgery: a systematic review of neuroimaging findings
B. Davidson, H. Suresh, M. Goubran, J.S. Rabin, Y. Meng, K. Mithani, C.B. Pople, P. Giacobbe, C. Hamani, N. Lipsman

Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives
P. Li, R.-X. Jing, R.-J. Zhao, L. Shi, H.-Q. Sun, Z. Ding, X. Lin, L. Lu, Y. Fan

Volumetric brain differences in clinical depression in association with anxiety: a systematic review with meta-analysis
D.A. Espinoza Oyarce, M.E. Shaw, K. Alateeq, N. Cherbuin

Differing functional mechanisms underlie cognitive control deficits in psychotic spectrum disorders
D.D. Stephenson, A.A. El Shaikh, N.A. Shaff, J.R. Bustillo, A.B. Dodd, C.J. Wertz, S.G. Ryman, F.M. Hanlon, J.P. Hogeveen, J.M. Ling, R.A. Yeo, S.F. Stromberg, D.S. Lin, S. Abrams, A.R. Mayer

Psychopharmacology for the Clinician

Therapeutic abstention in the treatment of depression in first-episode psychosis
P. Sabesan, L. Palaniyappan

September 2020

J Psychiatry Neurosci 2020;45(5)


Orphans to the rescue: orphan G-protein coupled receptors as new antidepressant targets
P.R. Albert

Review Paper

The orbitofrontal cortex, food intake and obesity
L.T. Seabrook, S.L. Borgland

Research Papers

Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: an open-label clinical trial
V.M. Tang, D.M. Blumberger, J. Dimitrova, A. Throop, S.M. McClintock, D. Voineskos, J. Downar, Y. Knyahnytska, B.H. Mulsant, P.B. Fitzgerald, Z.J. Daskalakis

Deficits of entropy modulation of the EEG: A biomarker for altered function in schizophrenia and bipolar disorder?
V. Molina, A. Lubeiro, R. de Luis Garcia, J. Gomez-Pilar, O. Martín-Santiago, M. Iglesias-Tejedor, P. Holgado-Madera, R. Segarra-Echeverría, M. Recio-Barbero, P. Núñez, M.K. Haidar, J. Fernández-Sevillano, J. Sanz-Fuentenebro

Anatomic alterations across amygdala subnuclei in medication-free patients with obsessive–compulsive disorder
L. Zhang, X. Hu, L. Lu, B. Li, X. Hu, X. Bu, H. Li, S. Tang, Y. Gao, Y. Yang, J.A. Sweeney, Q. Gong, X. Huang

Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment
V. Martin, L. Mathieu, J. Diaz, H. Salman, J. Alterio, C. Chevarin, L. Lanfumey, M. Hamon, M.C. Austin, M. Darmon, C.A. Stockmeier, J. Masson

Effectiveness and safety of neuroablation for severe and treatment-resistant obsessive–compulsive disorder: a systematic review and meta-analysis
Y. Lai, T. Wang, C. Zhang, G. Lin, V. Voon, J. Chang, B. Sun

Psychopharmacology for the Clinician

Treating anxious syndromes with pregabalin in patients with psychosis
N. Garel, D. Bloom, R. Joober

July 2020

J Psychiatry Neurosci 2020;45(4)


Adapting to the impact of COVID-19 on mental health: an international perspective
R.K. Thomas, R. Suleman, M. Mackay, L. Hayer, M. Singh, C.U. Correll, S. Dursun

Research Papers

Neural bases of the clinical and neurocognitive differences between earlyand late-onset obsessive–compulsive disorder
T. Kim, S. Kwak, J.-W. Hur, J. Lee, W.-G. Shin, T.Y. Lee, M. Kim, J.S. Kwon

Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder
D.C.W. Klooster, I.N. Vos, K. Caeyenberghs, A. Leemans, S. David, R.M.H. Besseling, A.P. Aldenkamp, C. Baeken

Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa
F. Bernardoni, N. Bernhardt, S. Pooseh, J.A. King, D. Geisler, F. Ritschel, I. Boehm, M. Seidel, V. Roessner, M.N. Smolka, S. Ehrlich

High-frequency versus theta burst transcranial magnetic stimulation for the treatment of poststroke cognitive impairment in humans
P.-Y. Tsai, W.-S. Lin, K.-T. Tsai, C.-Y. Kuo, P.-H. Lin

Transcranial magnetic stimulation over the right temporoparietal junction influences the sense of agency in healthy humans
G.A. Zito, L.B. Anderegg, K. Apazoglou, R.M. Müri, R. Wiest, M.G. Holtforth, S. Aybek

Trauma, treatment and Tetris: video gaming increases hippocampal volume in male patients with combat-related posttraumatic stress disorder
O. Butler, K. Herr, G. Willmund, J. Gallinat, S. Kühn, P. Zimmermann

Hippocampal and parahippocampal volumes vary by sex and traumatic life events in children
A.S. Badura-Brack, M.S. Mills, C.M. Embury, M.M. Khanna, A. Klanecky Earl, J.M. Stephen, Y.-P. Wang, V.D. Calhoun, T.W. Wilson

Letters to the Editor

Clozapine and COVID-19
G. Remington, V. Powell

The authors respond
D. Siskind, W.G. Honer, S. Clark, C.U. Correll, A. Hasan, O. Howes, J.M. Kane, D.L. Kelly, R. Laitman, J. Lee, J.H. MacCabe, N. Myles, J. Nielsen, P.F. Schulte, D. Taylor, H. Verdoux, A. Wheeler, O. Freudenreich

Psychopharmacology for the Clinician

Long-acting injectable antipsychotics: choosing the right dose
D. Carlone, N. Delva

May 2020

J Psychiatry Neurosci 2020;45(3)


Seeing the bigger picture: multimodal neuroimaging to investigate neuropsychiatric illnesses
E. Plitman, R. Patel, M.M. Chakravarty

Review Paper

Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic review
J. Singh, E. Lanzarini, P. Santosh

Research Papers

CACNA1C polymorphism and brain cortical structure in bipolar disorder
E. Smedler, C. Abé, E. Pålsson, M. Ingvar, M. Landén

Genetic and environmental influences on corticostriatal circuits in twins with autism
J.P. Hegarty II, L.C. Lazzeroni, M.M. Raman, J.F. Hallmayer, S.C. Cleveland, O.N. Wolke, J.M. Phillips, A.L. Reiss, A.Y. Hardan

Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial
K.W. Miskowiak, J.L. Forman, M. Vinberg, H.R. Siebner, L.V. Kessing, J. Macoveanu

Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa
I. Boehm, E. Walton, N. Alexander, V.-L. Batury, M. Seidel, D. Geisler, J.A. King, K. Weidner, V. Roessner, S. Ehrlich

Frontoparietal and salience network alterations in obsessive–compulsive disorder: insights from independent component and sliding time window analyses
D.A. Gürsel, L. Reinholz, B. Bremer, B. Schmitz-Koep, N. Franzmeier, M. Avram, K. Koch

Psychopharmacology for the Clinician

Consensus statement on the use of clozapine during the COVID-19 pandemic
D. Siskind, W.G. Honer, S. Clark, C. U. Correll, A. Hasan, O. Howes, J.M. Kane, D.L. Kelly, R. Laitman, J. Lee, J.H. MacCabe, N. Myles, J. Nielsen, P.F. Schulte, D. Taylor, H. Verdoux, A. Wheeler, O. Freudenreich


In memoriam: Glenda MacQueen (1965–2020)
S.L. Bray, V.H. Taylor, P. Arnold

CCNP News and Views

Canadian College of Neuropsychopharmacology 2020 award winners

March 2020

J Psychiatry Neurosci 2020;45(2)


Are mental disorders orphan diseases?
N. Garel, R. Joober

Research Papers

Melatonin suppression by melanopsin-weighted light in patients with bipolar I disorder compared to healthy controls
P. Ritter, F. Wieland, D.J. Skene, A. Pfennig, M. Weiss, M. Bauer, E. Severus, H. Güldner, C. Sauer, B. Soltmann, S. Neumann

Impaired cognitive performance under psychosocial stress in cannabis-dependent men is associated with attenuated precuneus activity
W. Zhao, K. Zimmermann, X. Zhou, F. Zhou, M. Fu, C. Dernbach, D. Scheele, B. Weber, M. Eckstein, R. Hurlemann, K.M. Kendrick, B. Becker

Altered response to risky decisions and reward in patients with obsessive–compulsive disorder
P.S. Moreira, J. Macoveanu, P. Marques, A. Coelho, R. Magalhães, H.R. Siebner, J.M. Soares, N. Sousa, P. Morgado

Intact value-based decision-making during intertemporal choice in women with remitted anorexia nervosa? An fMRI study
J.A. King, F. Bernardoni, D. Geisler, F. Ritschel, A. Doose, S. Pauligk, K. Pásztor, K. Weidner, V. Roessner, M.N. Smolka, S. Ehrlich

Brain structural correlates of alexithymia in patients with major depressive disorder
K. Förster, V. Enneking, K. Dohm, R. Redlich, S. Meinert, A.I. Geisler, E.J. Leehr, H. Kugel, B.T. Baune, V. Arolt, P. Zwitserlood, D. Grotegerd, U. Dannlowski

Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness
V. Drobinin, H. Van Gestel, A. Zwicker, L. MacKenzie, J. Cumby, V.C. Patterson, E. Howes Vallis, N. Campbell, T. Hajek, C.A. Helmick, M.H. Schmidt, M. Alda, C.V. Bowen, R. Uher

Quantitative tractography reveals changes in the corticospinal tract in drug-naïve children with attention-deficit/hyperactivity disorder
X. Bu, C. Yang, K. Liang, Q. Lin, L. Lu, L. Zhang, H. Li, Y. Gao, S. Tang, X. Hu, Y. Wang, X. Hu, M. Wang, X. Huang


In memoriam: Chawki Benkelfat (1953–2020)
M. Leyton

Psychopharmacology for the Clinician

Mu-opioid antagonism in the treatment of cannabis use disorder
O. Kebir, X. Laqueille, F. Mouaffak

January 2020

J Psychiatry Neurosci 2020;45(1)


We need an operational framework for heterogeneity in psychiatric research
A. Nunes, T. Trappenberg, M. Alda

Research Papers

Magnetic resonance imaging texture predicts progression to dementia due to Alzheimer disease earlier than hippocampal volume
S. Lee, H. Lee, K.W. Kim; for the Alzheimer’s Disease Neuroimaging Initiative

Neurobiological commonalities and distinctions among 3 major psychiatric disorders: a graph theoretical analysis of the structural connectome
S. Wang, G. Gong, S. Zhong, J. Duan, Z. Yin, M. Chang, S. Wei, X. Jiang, Y. Zhou, Y. Tang, F. Wang

Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trial
E. Hilland, N.I. Landrø, C.J. Harmer, M. Browning, L.A. Maglanoc, R. Jonassen

A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction
J. Sun, H.R. Kranzler, J. Gelernter, J. Bi

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression
T. Sankar, M.M. Chakravarty, N. Jawa, S.X. Li, P. Giacobbe, S.H. Kennedy, S.J. Rizvi, H.S. Mayberg, C. Hamani, A.M. Lozano

Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI
J. Gong, J. Wang, X. Luo, G. Chen, H. Huang, R. Huang, L. Huang, Y. Wang

Reviewers 2019

Reviewers 2019

Psychopharmacology for the Clinician

Kleptomania treated with naltrexone in a patient with intellectual disability
F. Mouaffak, S. Hamzaoui, O. Kebir, X. Laqueille

November 2019

J Psychiatry Neurosci 2019;44(6)


Sex: a key consideration in understanding the etiology of psychiatric disorders and improving treatment
C. Tannenbaum, P. Boksa

Review Paper

Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosis
L. Palaniyappan


Ketamine for chronic depression: two cautionary tales
J. Talbot, J.L. Phillips, P. Blier

Research Papers

Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy
J.G. Levitt, G. Kalender, J. O’Neill, J.P. Diaz, I.A. Cook, N. Ginder, D. Krantz, M.J. Minzenberg, N. Vince-Cruz, L.D. Nguyen, J.R. Alger, A.F. Leuchter

Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study
A. Alves-Pinto, O.G. Rus, T.J. Reess, A. Wohlschläger, G. Wagner, G. Berberich, K. Koch

Time heals all wounds? A 2-year longitudinal diffusion tensor imaging study in major depressive disorder
J. Repple, D. Zaremba, S. Meinert, D. Grotegerd, R. Redlich, K. Förster, K. Dohm, N. Opel, T. Hahn, V. Enneking, E.J. Leehr, J. Böhnlein, F. Dzvonyar, L. Sindermann, N. Winter, J. Goltermann, H. Kugel, J. Bauer, W. Heindel, V. Arolt, U. Dannlowski

Cannabis involvement and neuropsychological performance: findings from the Human Connectome Project
T. Petker, M.M. Owens, M.T. Amlung, A. Oshri, L.H. Sweet, J. MacKillop

Large-scale evidence for an association between low-grade peripheral inflammation and brain structural alterations in major depression in the BiDirect study
N. Opel, M. Cearns, S. Clark, C. Toben, D. Grotegerd, W. Heindel, H. Kugel, A. Teuber, H. Minnerup, K. Berger, U. Dannlowski, B.T. Baune

Psychopharmacology for the Clinician

Treatment of first-episode psychosis in patients with autism-spectrum disorder and intellectual deficiency
N. Garel, R. Joober

CCNP News and Views

The 42nd Annual Meeting of the Canadian College of Neuropsychopharmacology
A. Larosa, M. Nath, L.K. Srivastava

September 2019

J Psychiatry Neurosci 2019;44(5)


Cannabis legalization: Did we make a mistake? Update 2019
M. Leyton

Research Papers

5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression
L.J. Steinberg, M.D. Underwood, M.J. Bakalian, S.A. Kassir, J.J. Mann, V. Arango

Nonacceptance of negative emotions in women with borderline personality disorder: association with neuroactivity of the dorsal striatum
A. Lamers, M. Toepper, S. Carvalho Fernando, N. Schlosser, E. Bauer, F. Woermann, M. Driessen, T. Beblo

Resting-state connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in clinical anxiety
S. Torrisi, G.M. Alvarez, A.X. Gorka, B. Fuchs, M. Geraci, C. Grillon, M. Ernst

Altered thalamo–cortical and occipital–parietal–temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studies
S. Gaudio, F. Carducci, C. Piervincenzi, G. Olivo, H.B. Schiöth

Adult patients with ADHD differ from healthy controls in implicit, but not explicit, emotion regulation
L. Materna, C.D. Wiesner, A. Shushakova, J. Trieloff, N. Weber, A. Engell, R.I. Schubotz, J. Bauer, A. Pedersen, P. Ohrmann

Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes
B. Torrico, A.D. Shaw, R. Mosca, N. Vivó-Luque, A. Hervás, N. Fernàndez-Castillo, P. Aloy, M. Bayés, J.M. Fullerton, B. Cormand, C. Toma


Young Researchers’ Brain Health Research Day Joint Conference: “Game of Hormones: Why Sex Matters for Brain Health”

July 2019

J Psychiatry Neurosci 2019;44(4)


The microbiome and mental health: Hope or hype?
V.H. Taylor

Review Paper

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols
G.M. MacQueen, S. Hassel, S.R. Arnott, J. Addington, C.R. Bowie, S.L. Bray, A.D. Davis, J. Downar, J.A. Foster, B.N. Frey, B.I. Goldstein, G.B. Hall, K.L. Harkness, J. Harris, R.W. Lam, C. Lebel, R. Milev, D.J. Müller, S.V. Parikh, S. Rizvi, S. Rotzinger, G.B. Sharma, C.N. Soares, G. Turecki, F. Vila-Rodriguez, J. Yu, M. Zamyadi, S.C. Strother, S.H. Kennedy; on behalf of the CAN-BIND Investigator Team

Research Papers

Adolescent depression and brain development: evidence from voxel-based morphometry
J. Straub, R. Brown, K. Malejko, M. Bonenberger, G. Grön, P.L. Plener, B. Abler

An artificial neural network model for clinical score prediction in Alzheimer disease using structural neuroimaging measures
N. Bhagwat, J. Pipitone, A.N. Voineskos, M.M. Chakravarty, Alzheimer’s Disease Neuroimaging Initiative

Changes of motor cortical excitability and response inhibition in patients with obsessive–compulsive disorder
J.I. Kang, D.Y. Kim, C. Lee, C-H. Kim, S.J. Kim

Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study
D.L. Kelly, H.K. Demyanovich, K.M. Rodriguez, D. Čiháková, M.V. Talor, R. P. McMahon, C. M. Richardson, G. Vyas, H.A. Adams, S.M. August,  A. Fasano,  N.G. Cascella, S.M. Feldman, F. Liu, M.A. Sayer, M.M. Powell, H.J. Wehring, R.W. Buchanan, J.M. Gold, W.T. Carpenter, Jr., W.W. Eaton

Neural response to emotional faces in monozygotic twins: association with familial risk of affective disorders
I. Meluken, N. Ottesen, C. Harmer, J. Macoveanu, H. Siebner, L. Kessing, M. Vinberg, K. Miskowiak

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study
A.E. Leeuwis, N.A. Weaver, J.M. Biesbroek, L.G. Exalto, H.J. Kuijf, A.M. Hooghiemstra, N.D. Prins, P. Scheltens, F. Barkhof, W.M. van der Flier, G.J. Biessels; on behalf of the TRACE-VCI study group

Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study
L. Lim, H. Hart, H. Howells, M.A. Mehta, A. Simmons, K. Mirza, K. Rubia

Psychopharmacology for the Clinician

Management of sexual adverse effects induced by atypical antipsychotic medication
L. Downing, D.D. Kim, R.M. Procyshyn, P. Tibbo

May 2019

J Psychiatry Neurosci 2019;44(3)


Adult neuroplasticity: A new “cure” for major depression?
P.R. Albert

Review Papers

Unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression: a meta-analysis of randomized controlled trials over 2 decades
S. Sehatzadeh, Z.J. Daskalakis, B. Yap, H.-A. Tu, S. Palimaka, J.M. Bowen, D.J. O’Reilly

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm
P.R. Albert, B. Le François, F. Vahid-Ansari

Research Papers

Multisensory integration underlying body-ownership experiences in schizophrenia and offspring of patients: a study using the rubber hand illusion paradigm
M. Prikken, A. van der Weiden, H. Baalbergen, M.H.J. Hillegers, R.S. Kahn, H. Aarts, N.E.M. van Haren

Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood
I. Lange, L. Goossens, J. Bakker, S. Michielse, R. van Winkel, S. Lissek, N. Leibold, M. Marcelis, M. Wichers, J. van Os, T. van Amelsvoort, K. Schruers

Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation
Y. Fukuda, T. Katthagen, L. Deserno, L. Shayegan, J. Kaminski, A. Heinz, F. Schlagenhauf

A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women
H. Steiger, L. Booij, E. Kahan, K. McGregor, L. Thaler, E. Fletcher, A. Labbe, R. Joober, M. Israël, M. Szyf, L.B. Agellon, L. Gauvin, A. St-Hilaire, E. Rossi

CCNP News and Views

Canadian College of Neuropsychopharmacology 2019 award winners

Psychopharmacology for the Clinician

N-Acetylcysteine augmentation in refractory obsessive–compulsive disorder
S. Bhaskara

March 2019

J Psychiatry Neurosci 2019;44(2)


Cannabis: A potential efficacious intervention for PTSD or simply snake oil?
A. Abizaid, Z. Merali, H. Anisman

Research Papers

Age-related deficits in intracortical myelination in young adults with bipolar disorder type I
M. Sehmbi, C.D. Rowley, L. Minuzzi, F. Kapczinski, J.M. Kwiecien, N.A. Bock, B.N. Frey

Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis
X. Wang, Q. Luo, F. Tian, B. Cheng, L. Qiu, S. Wang, M. He, H. Wang, M. Duan, Z. Jia

Cerebral blood flow in striatal regions is associated with apathy in patients with schizophrenia
K. Schneider, L. Michels, M.N. Hartmann-Riemer, A. Burrer, P.N. Tobler, P. Stämpfli, M. Kirschner, E. Seifritz, S. Kaiser

GABA levels and TSPO expression in people at clinical high risk for psychosis and healthy volunteers: a PET-MRS study
T. Da Silva, S. Hafizi, P.M. Rusjan, S. Houle, A.A. Wilson, I. Prce, N. Sailasuta, R. Mizrahi

Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive–compulsive disorder
H. Lei, J. Lai, X. Sun, Q. Xu, G. Feng

Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
M. Chang, E.K. Edmiston, F.Y. Womer, Q. Zhou, S. Wei, X. Jiang, Y. Zhou, Y. Ye, H. Huang, X.-N. Zuo, K. Xu, Y. Tang,
F. Wang

Psychopharmacology for the Clinician

Treating resistant depression with 2 forms of convulsive therapy: a clinical case study
A.A. Daskalakis, Z.J. Daskalakis